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We used propensity score matching to compare skeletal muscle characteristics of individuals from the Health ABC study that did not consume aspirin or any other COX\u2010inhibiting drugs (non\u2010consumers, <jats:italic>n<\/jats:italic>\u2009=\u2009497, 74\u2009\u00b1\u20093\u2009year, 168\u2009\u00b1\u20099\u2009cm, 75.1\u2009\u00b1\u200913.8\u2009kg, 33.1\u2009\u00b1\u20097.4% body fat, 37% women, 34% black) to those that consumed aspirin daily (and not any other COX\u2010inhibiting drugs) and for at least 1\u2009year (aspirin consumers, <jats:italic>n<\/jats:italic>\u2009=\u2009515, 74\u2009\u00b1\u20093\u2009year, 168\u2009\u00b1\u20099\u2009cm, 76.2\u2009\u00b1\u200913.6\u2009kg, 33.8\u2009\u00b1\u20097.1% body fat, 39% women, 30% black, average aspirin consumption: 6\u2009year). Subjects were matched (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05) based on age, height, weight, % body fat, sex, and race (propensity scores: 0.33\u2009\u00b1\u20090.09 vs. 0.33\u2009\u00b1\u20090.09, <jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). There was no difference between non\u2010consumers and aspirin consumers for computed tomography\u2010determined muscle size of the quadriceps (103.5\u2009\u00b1\u20090.9 vs. 104.9\u2009\u00b1\u20090.8\u2009cm<jats:sup>2<\/jats:sup>, <jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05) or hamstrings (54.6\u2009\u00b1\u20090.5 vs. 54.9\u2009\u00b1\u20090.5\u2009cm<jats:sup>2<\/jats:sup>, <jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05), or quadriceps muscle strength (111.1\u2009\u00b1\u20092.0 vs. 111.7\u2009\u00b1\u20092.0\u2009Nm, <jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). However, muscle attenuation (i.e., density) was higher in the aspirin consumers in the quadriceps (40.9\u2009\u00b1\u20090.3 vs. 44.4\u2009\u00b1\u20090.3 Hounsfield unit [HU], <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) and hamstrings (27.7\u2009\u00b1\u20090.4 vs. 33.2\u2009\u00b1\u20090.4\u2009HU, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). These cross sectional data suggest that chronic aspirin consumption does not influence age\u2010related skeletal muscle atrophy, but does influence skeletal muscle composition in septuagenarians. Prospective longitudinal investigations remain necessary to better understand the influence of chronic COX regulation on aging skeletal muscle health.<\/jats:p>","DOI":"10.14814\/phy2.15669","type":"journal-article","created":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T17:01:09Z","timestamp":1682010069000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Influence of aspirin on aging skeletal muscle: Insights from a cross\u2010sectional cohort of septuagenarians"],"prefix":"10.14814","volume":"11","author":[{"given":"William A.","family":"Fountain","sequence":"first","affiliation":[{"name":"Human Performance Laboratory Ball State University  Muncie Indiana United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Naruse","sequence":"additional","affiliation":[{"name":"Human Performance Laboratory Ball State University  Muncie Indiana United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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