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Heavy resistance exercise is known to induce large transient elevations in BP, which are translated into perturbations of CBF, and may alter dCA in the immediate aftermath. This study aimed to better quantify the time course of any acute alterations in dCA after resistance exercise. Following familiarisation to all procedures, 22 (14 male) healthy young adults (22\u2009\u00b1\u20092\u2009years) completed an experimental trial and resting control trial, in a counterbalanced order. Repeated squat\u2010stand manoeuvres (SSM) at 0.05 and 0.10\u2009Hz were used to quantify dCA before, and 10 and 45\u2009min after four sets of ten repetition back squats at 70% of one repetition maximum, or time matched seated rest (control). Diastolic, mean and systolic dCA were quantified by transfer function analysis of BP (finger plethysmography) and middle cerebral artery blood velocity (transcranial Doppler ultrasound). Mean gain (<jats:italic>p<\/jats:italic>\u2009=\u20090.02;<jats:italic>d<\/jats:italic>\u2009=\u20090.36) systolic gain (<jats:italic>p<\/jats:italic>\u2009=\u20090.01;<jats:italic>d<\/jats:italic>\u2009=\u20090.55), mean normalised gain (<jats:italic>p<\/jats:italic>\u2009=\u20090.02;<jats:italic>d<\/jats:italic>\u2009=\u20090.28) and systolic normalised gain (<jats:italic>p<\/jats:italic>\u2009=\u20090.01;<jats:italic>d<\/jats:italic>\u2009=\u20090.67) were significantly elevated above baseline during 0.10\u2009Hz SSM 10\u2010min post resistance exercise. This alteration was not present 45\u2009min post\u2010exercise, and dCA indices were never altered during SSM at 0.05\u2009Hz. dCA metrics were acutely altered 10\u2009min post resistance exercise at the 0.10\u2009Hz frequency only, which indicate changes in the sympathetic regulation of CBF. These alterations recovered 45\u2009min post\u2010exercise.<\/jats:p>","DOI":"10.14814\/phy2.15676","type":"journal-article","created":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T01:15:02Z","timestamp":1682558102000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Resistance exercise acutely elevates dynamic cerebral autoregulation gain"],"prefix":"10.14814","volume":"11","author":[{"given":"Oliver J.","family":"Smail","sequence":"first","affiliation":[{"name":"Exeter Head Impacts, Brain Injury and Trauma (ExHIBIT), Public Health and Sport Sciences University of Exeter Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Clarke","sequence":"additional","affiliation":[{"name":"Exeter Head Impacts, Brain Injury and Trauma (ExHIBIT), Public Health and Sport Sciences University of Exeter Exeter 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