{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:33:35Z","timestamp":1792096415156,"version":"4.4.0"},"reference-count":52,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T00:00:00Z","timestamp":1685664000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Physiological properties and function of the lymphatic system is still somewhat of a mystery. We report the current knowledge about human lymphatic vessel contractility and capability of adaptation. A literature search in PubMed identified studies published January 2000\u2013September 2022. Inclusion criteria were studies investigating parameters related to contraction frequency, fluid velocity, and lymphatic pressure in vivo and ex vivo in human lymphatic vessels. The search returned 2885 papers of which 28 met the inclusion criteria. In vivo vessels revealed baseline contraction frequencies between 0.2\u2009\u00b1\u20090.2 and 1.8\u2009\u00b1\u20090.1\u2009min\n                    <jats:sup>1<\/jats:sup>\n                    , velocities between 0.008\u2009\u00b1\u20090.002 and 2.3\u2009\u00b1\u20090.3\u2009cm\/s, and pressures between 4.5 (range 0.5\u20139.2) and 60.3\u2009\u00b1\u20092.8\u2009mm Hg. Gravitational forces, hyperthermia, and treatment with nifedipine caused increases in contraction frequency. Ex vivo lymphatic vessels displayed contraction frequencies between 1.2\u2009\u00b1\u20090.1 and 5.5\u2009\u00b1\u20091.2\u2009min\n                    <jats:sup>\u22121<\/jats:sup>\n                    . Exposure to agents affecting cation and anion channels, adrenoceptors, HCN channels, and changes in diameter\u2010tension properties all resulted in changes in functional parameters as known from the blood vascular system. We find that the lymphatic system is dynamic and adaptable. Different investigative methods yields alternating results. Systematic approaches, consensus on investigative methods, and larger studies are needed to fully understand lymphatic transport and apply this in a clinical context.\n                  <\/jats:p>","DOI":"10.14814\/phy2.15697","type":"journal-article","created":{"date-parts":[[2023,6,3]],"date-time":"2023-06-03T02:49:20Z","timestamp":1685760560000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The transport function of the human lymphatic system\u2014A systematic review"],"prefix":"10.14814","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5208-8353","authenticated-orcid":false,"given":"Lene","family":"Thorup","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery Copenhagen University Hospital  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen 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