{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T17:41:14Z","timestamp":1791481274876,"version":"4.3.4"},"reference-count":41,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T00:00:00Z","timestamp":1690156800000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001509","name":"Royal Society of New Zealand","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001509","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Chronic use of the oral contraceptive pill (OCP) is reported to increase C\u2010reactive protein (CRP) levels and increase the risk of cardiovascular disease in premenopausal females.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A secondary analysis of data from two research studies in eumenorrheic (<jats:italic>n<\/jats:italic>\u2009=\u20098) and OCP (<jats:italic>n<\/jats:italic>\u2009=\u20098) female athletes. Basal CRP and iron parameters were included in the analysis. Sample collection occurred following a standardized exercise and nutritional control for 24\u2009h. Eumenorrheic females were tested in the early\u2010follicular and mid\u2010luteal phases, and the OCP users were tested in <jats:italic>quasi\u2010<\/jats:italic>follicular and <jats:italic>quasi\u2010<\/jats:italic>luteal phases (both active pill periods).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A main effect for group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) indicated that average CRP concentration was higher in OCP users compared with eumenorrheic females, regardless of the day of measurement within the cycle. Results demonstrate a degree of iron parameters moderation throughout the menstrual cycle that is influenced by basal CRP levels; however, no linear relationship with CRP, serum iron, and ferritin was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Basal CRP values were consistently higher in the OCP group despite participants being in a rested state. These results may indicate a potential risk of cardiovascular disease in prolonged users of the OCP when compared to eumenorrheic female athletes.<\/jats:p><\/jats:sec>","DOI":"10.14814\/phy2.15777","type":"journal-article","created":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T00:32:58Z","timestamp":1690245178000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Does chronic oral contraceptive use detrimentally affect <scp>C\u2010reactive<\/scp> protein or iron status for <scp>endurance\u2010trained<\/scp> women?"],"prefix":"10.14814","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8434-9730","authenticated-orcid":false,"given":"C. 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