{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T09:47:01Z","timestamp":1793958421724,"version":"4.8.0"},"reference-count":52,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T00:00:00Z","timestamp":1694217600000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002668","name":"Abant Izzet Baysal \u00dcniversitesi","doi-asserted-by":"publisher","award":["2021.08.32.1488."],"award-info":[{"award-number":["2021.08.32.1488."]}],"id":[{"id":"10.13039\/501100002668","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of our study is to investigate the electrophysiological and anti\u2010inflammatory effects of diclofenac potassium on epileptiform activity, which is the liquid form of diclofenac, and frequently used clinically for inflammatory process by inhibiting cyclooxygenase enzyme (COX). Wistar rats aged 2\u20134\u2009months were divided into Epilepsy, Diazepam, Diclofenac potassium, and Diazepam+diclofenac potassium groups. Diazepam and diclofenac potassium were administered intraperitoneally 30\u2009min after the epileptiform activity was created with penicillin injected intracortically under anesthesia. After the electrophysiological recording was taken in the cortex for 125\u2009min, interleukin\u20101\u03b2 (IL\u20101\u03b2), interleukin\u20106 (IL\u20106), and tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1) were evaluated by the ELISA in the serums. No change was observed between the groups in serum IL\u20101\u03b2, IL\u20106, and TNF\u2010\u03b1 values. It was observed that the co\u2010administration of diclofenac potassium and diazepam at 51\u201355, 56\u201360, 61\u201365, 111\u2013115, and 116\u2013120\u2009min was more effective in reducing spike amplitude than diclofenac potassium alone (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Single\u2010dose diclofenac potassium did not have an anti\u2010inflammatory effect in epileptiform activity but both diazepam and diclofenac potassium reduced the epileptiform activity.<\/jats:p>","DOI":"10.14814\/phy2.15800","type":"journal-article","created":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T07:50:40Z","timestamp":1694245840000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Electrophysiologic and anti\u2010inflammatorial effects of cyclooxygenase inhibition in epileptiform activity"],"prefix":"10.14814","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8791-235X","authenticated-orcid":false,"given":"Canan","family":"Akunal\u00a0T\u00fcrel","sequence":"first","affiliation":[{"name":"Department of Neurology Bolu Abant Izzet Baysal University Medical School  Bolu Merkez\/Bolu Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3394-2438","authenticated-orcid":false,"given":"H\u00fcmeyra","family":"\u00c7elik","sequence":"additional","affiliation":[{"name":"Department of Physiology Alanya Alaaddin Keykubat University Medical School  Antalya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8212-7149","authenticated-orcid":false,"given":"Ayhan","family":"\u00c7etinkaya","sequence":"additional","affiliation":[{"name":"Department of Physiology Bolu Abant Izzet Baysal University Medical School  Bolu Merkez\/Bolu Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9865-1685","authenticated-orcid":false,"given":"\u0130dris","family":"T\u00fcrel","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Bolu Abant Izzet Baysal University Medical School  Bolu Merkez\/Bolu Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2006.06.009"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-1758754"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20198"},{"key":"e_1_2_10_5_1","first-page":"11","article-title":"Effects of non\u2010steroidal anti\u2010inflammatory drugs on anticonvulsant activity of diazepam in mice","volume":"1","author":"Almaghour H. G.","year":"2014","journal-title":"Pharmacy & Pharmacology International Journal"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-015-0392-z"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.4149\/BLL_2020_006"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.5799\/ahinjs.01.2011.01.0224"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/106002809202600106"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1757-7241-17-43"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2008.49.1.1"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2009.01.002"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-005-0021-y"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2022.121300"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2006.06.003"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-020-03054-7"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13188"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0173(89)90003-9"},{"key":"e_1_2_10_19_1","unstructured":"Ghlichloo I. &Gerriets V.(2021).Nonsteroidal anti\u2010inflammatory drugs (NSAIDs).https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK547742\/"},{"key":"e_1_2_10_20_1","first-page":"392","article-title":"Overview of drugs used for epilepsy and seizures: Etiology, diagnosis, and treatment","volume":"35","author":"Goldenberg M. M.","year":"2010","journal-title":"Pharmacy and Therapeutics"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12784"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-2478(94)00158-8"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2010.07.032"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.163.1.111"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.11131\/2018\/101384"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13965"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ddstr.2008.05.006"},{"key":"e_1_2_10_28_1","first-page":"147","article-title":"Models of experimental epilepsy","volume":"14","author":"Marangoz C.","year":"1997","journal-title":"Ondokuz May\u0131s \u00dcniversitesi T\u0131p Dergisi"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-011-0039-z"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/epi4.12550"},{"key":"e_1_2_10_31_1","first-page":"CD008659","article-title":"Single dose oral analgesics for acute postoperative pain in adults \u2010 an overview of Cochrane reviews","volume":"9","author":"Moore R. A.","year":"2015","journal-title":"Cochrane Database System Reviews"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.104.007112"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.12.028"},{"issue":"885","key":"e_1_2_10_34_1","first-page":"2001","article-title":"Increased absorption rate of diclofenac from fast acting formulations containing its potassium salt","volume":"51","author":"Reiner V.","year":"2001","journal-title":"Arzneimittelforchung"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2009.09.004"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-6989(85)90092-X"},{"key":"e_1_2_10_37_1","first-page":"56573","article-title":"Pentylenetetrazole\u2010induced kindling mouse model","volume":"12","author":"Shimada T.","year":"2018","journal-title":"Journal of Visualized Experiments"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2013.12.025"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R800094-JLR200"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a022426"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2012.08.012"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(81)90414-3"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.09.093"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2017.12.004"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002023"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2016.12.010"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2011.09.033"},{"key":"e_1_2_10_48_1","first-page":"163","article-title":"Inflammation and epilepsy. Handbook","volume":"17","author":"Vezzani A.","year":"2012","journal-title":"Clinical Neurology"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2016.08.020"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2014.10.001"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1684\/epd.2007.0144"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2012.02710.x"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1097\/AIA.0b013e318034194e"}],"container-title":["Physiological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.15800","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T10:30:26Z","timestamp":1707301826000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.14814\/phy2.15800"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":52,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.14814\/phy2.15800"],"URL":"https:\/\/doi.org\/10.14814\/phy2.15800","archive":["Portico"],"relation":{},"ISSN":["2051-817X","2051-817X"],"issn-type":[{"value":"2051-817X","type":"print"},{"value":"2051-817X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"2023-01-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e15800"}}