{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T17:44:01Z","timestamp":1773769441433,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T00:00:00Z","timestamp":1693440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN\u20102019\u201004438"],"award-info":[{"award-number":["RGPIN\u20102019\u201004438"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Obstructive sleep apnea (OSA) is characterized by chronic intermittent hypoxemia, which is associated with progressive loss of kidney function, where postprandial fluctuations in renal physiology may further compromise oxygen supply and kidney function. Therefore, we measured biomarkers of acute kidney injury (AKI) following a high\u2010fat meal with and without intermittent hypoxemia. Eighteen healthy young men (mean age [SD]: 22.7\u2009years [3.1]) and seven middle\u2010aged to older individuals with OSA (54.4\u2009years [6.4]) consumed a high\u2010fat meal during normoxia or intermittent hypoxemia (~15 hypoxic cycles per hour, ~85% oxyhemoglobin saturation) for 6\u2009h. We observed no changes in estimated glomerular filtration rate and plasma concentrations of creatinine, neutrophil gelatinase\u2010associated lipocalin (NGAL), and kidney injury molecule\u20101 (KIM\u20101) at any measured time points. In both groups, plasma concentrations of interleukin\u201018 (IL\u201018) increased after 6\u2009h during normoxia only (<jats:italic>p<\/jats:italic>\u2009=\u20090.033, <jats:italic>\u03b7<\/jats:italic><jats:sub>p<\/jats:sub><jats:sup>2<\/jats:sup>\u2009=\u20090.122), and plasma concentrations of liver\u2010type fatty acid\u2010binding protein (L\u2010FABP) transiently decreased after 3\u2009h in both conditions (<jats:italic>p<\/jats:italic>\u2009=\u20090.008, <jats:italic>\u03b7<\/jats:italic><jats:sub>p<\/jats:sub><jats:sup>2<\/jats:sup>\u2009=\u20090.152). These findings indicate that AKI biomarkers are not acutely elevated during the postprandial state with or without intermittent hypoxemia, suggesting that other mechanisms may play more important roles in the progression of kidney disease in OSA.<\/jats:p>","DOI":"10.14814\/phy2.15804","type":"journal-article","created":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T04:07:48Z","timestamp":1693541268000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["No impact of a high\u2010fat meal coupled with intermittent hypoxemia on acute kidney injury biomarkers in adults with and without obstructive sleep apnea"],"prefix":"10.14814","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1941-3174","authenticated-orcid":false,"given":"Nicholas","family":"Goulet","sequence":"first","affiliation":[{"name":"Behavioural and Metabolic Research Unit, School of Human Kinetics, Faculty of Health Sciences University of Ottawa  Ottawa Ontario Canada"},{"name":"Human and Environmental Physiology Research Unit, School of Human Kinetics, Faculty of Health Sciences University of Ottawa  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4192-474X","authenticated-orcid":false,"given":"Emily J.","family":"Tetzlaff","sequence":"additional","affiliation":[{"name":"Human and Environmental Physiology Research Unit, School of Human Kinetics, Faculty of Health Sciences University of Ottawa  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6983-9582","authenticated-orcid":false,"given":"Ren\u00e9e","family":"Morin","sequence":"additional","affiliation":[{"name":"Behavioural and Metabolic Research Unit, School of Human Kinetics, Faculty of Health Sciences University of Ottawa  Ottawa Ontario 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