{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T20:56:01Z","timestamp":1780520161460,"version":"3.54.1"},"reference-count":35,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T00:00:00Z","timestamp":1696464000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006727","name":"University of Kansas Medical Center","doi-asserted-by":"publisher","award":["Internal Medicine Start\u2010Up Funds"],"award-info":[{"award-number":["Internal Medicine Start\u2010Up Funds"]}],"id":[{"id":"10.13039\/100006727","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL142543"],"award-info":[{"award-number":["R01HL142543"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Idiopathic pulmonary fibrosis (IPF) is a progressive disease that impairs lung mechanical properties due to dysregulated extracellular matrix remodeling. Lung function assessment is an important physiological endpoint in the mouse model of pulmonary fibrosis (PF) that has gained a broader scientific acceptance in the field. IPF pathophysiology shows sex\u2010based differences, disproportionately affecting more men compared to women. Prior reports suggest that the circadian clock is perturbed during the pathogenesis of PF. We have comprehensively assessed the sex\u2010based differences and time\u2010of\u2010day response (at Zeitgeber time: ZT0\/6:00\u2009a.m. or ZT12\/6\u2009p.m.) in lung mechanics among sham (control) versus bleomycin (BLM)\u2010challenged female and male (C57BL\/6: WT) mice using Flexi\u2010vent. BLM challenge altered lung function significantly in males in both total lung (reduced dynamic compliance, and increased resistance and elastance) as well as lung tissue\u2010specific parameters (increased tissue elastance and tissue damping) but less pronounced in females. BLM\u2010challenged mice showed a time\u2010of\u2010day response in lung function at ZT0 versus ZT12, which was pronounced in the ZT0 BLM group. Overall, these findings provide a comprehensive analysis of altered lung function in female and male mice and the time\u2010of\u2010day difference in lung function parameters following BLM\u2010induced lung fibrosis.<\/jats:p>","DOI":"10.14814\/phy2.15828","type":"journal-article","created":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T01:31:04Z","timestamp":1696555864000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Lung mechanics showing sex\u2010based differences and circadian time\u2010of\u2010day response to bleomycin\u2010induced lung injury in mice"],"prefix":"10.14814","volume":"11","author":[{"given":"Chandrashekhar","family":"Prasad","sequence":"first","affiliation":[{"name":"Division of Pulmonary Critical Care and Sleep Medicine, Department of Internal Medicine University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santhosh Kumar","family":"Duraisamy","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Critical Care and Sleep Medicine, Department of Internal Medicine University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6742-3460","authenticated-orcid":false,"given":"Isaac Kirubakaran","family":"Sundar","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Critical Care and Sleep Medicine, Department of Internal Medicine University of Kansas Medical Center  Kansas City Kansas 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