{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:06:23Z","timestamp":1787022383047,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T00:00:00Z","timestamp":1701820800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["2016530"],"award-info":[{"award-number":["2016530"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008713","name":"Diabetes Australia Research Trust","doi-asserted-by":"publisher","award":["Y20G\u2010ZHAA"],"award-info":[{"award-number":["Y20G\u2010ZHAA"]}],"id":[{"id":"10.13039\/100008713","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Long ncRNAs (lncRNAs) have been shown to play a biological and physiological role in various tissues including the heart. We and others have previously established that the lncRNA\n                    <jats:italic>Oip5os1<\/jats:italic>\n                    (\n                    <jats:italic>1700020I14Rik<\/jats:italic>\n                    , OIP5\u2010AS1, Cyrano) is enriched in striated muscles, and its deletion in mice leads to defects in both skeletal and cardiac muscle function. In the present study, we investigated the impact of global\n                    <jats:italic>Oip5os1<\/jats:italic>\n                    deletion on cardiac function in the setting of streptozotocin (STZ)\u2010induced diabetes. Specifically, we studied male WT and KO mice with or without diabetes for 24\u2009weeks, and phenotyped animals for metabolic and cardiac endpoints. Independent of genotype, diabetes was associated with left ventricular diastolic dysfunction based on a fall in E'\/A' ratio. Deletion of\n                    <jats:italic>Oip5os1<\/jats:italic>\n                    in a setting of diabetes had no significant impact on ventricular function or ventricular weight, but was associated with left atrial dysfunction (reduced fractional shortening) and myopathy which was associated with anesthesia intolerance and premature death in the majority of KO mice tested during cardiac functional assessment. This atrial phenotype was not observed in WT diabetic mice. The most striking molecular difference was a reduction in the metabolic regulator ERRalpha in the atria of KO mice compared with WT mice. There was also a trend for a reduction in Serca2a. These findings highlight\n                    <jats:italic>Oip5os1<\/jats:italic>\n                    as a gene of interest in aspects of atrial function in the setting of diabetes, highlighting an additional functional role for this lncRNA in cardiac pathological settings.\n                  <\/jats:p>","DOI":"10.14814\/phy2.15869","type":"journal-article","created":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T12:40:53Z","timestamp":1701866453000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Deletion of the muscle enriched\n                    <scp>lncRNA<\/scp>\n                    Oip5os1 induces atrial dysfunction in male mice with diabetes"],"prefix":"10.14814","volume":"11","author":[{"given":"Aowen","family":"Zhuang","sequence":"first","affiliation":[{"name":"Baker Heart &amp; Diabetes Institute  Melbourne Victoria 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