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C57BL\/6J mice were treated with cisplatin via a single intraperitoneal injection (25\u2009mg\/kg) with or without UMB (40\u2009mg\/kg\/day) by gavage. Renal function, apoptosis, oxidative stress, inflammation, and mitochondrial function were analyzed to evaluate kidney injury. In\u00a0vitro, human proximal tubule epithelial cells were treated with cisplatin, with or without UMB, for 24\u2009h. Western blotting and immunohistochemistry were performed to explore the mechanisms underlying the nephroprotective effects of UMB. Cisplatin\u2010induced renal dysfunction, including increases in blood urea nitrogen, serum creatinine, and renal tubular injury indices (NGAL and KIM\u20101), were significantly attenuated by UMB treatment, along with renal phenotypic changes and renal tubular injury, as evidenced by improved renal histology. Moreover, NRF2 was activated by UMB pretreatment, along with the inhibition of oxidative stress and inflammatory response, as evidenced by decreased levels of antioxidant genes and inflammatory cytokines in cisplatin\u2010induced AKI. Our results demonstrate that UMB can protect against cisplatin\u2010induced nephrotoxicity, which is mediated by the NRF2 signaling pathway via antioxidant and anti\u2010inflammatory activities, suggesting the clinical potential of UMB for the treatment of AKI.<\/jats:p>","DOI":"10.14814\/phy2.15879","type":"journal-article","created":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T02:16:26Z","timestamp":1701310586000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Umbelliferone attenuates cisplatin\u2010induced acute kidney injury by inhibiting oxidative stress and inflammation via <scp>NRF2<\/scp>"],"prefix":"10.14814","volume":"11","author":[{"given":"Zhenle","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Pediatrics Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruofei","family":"Ning","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianying","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruixian","family":"Zang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5346-0279","authenticated-orcid":false,"given":"Suwen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong China"},{"name":"Nanjing Key Laboratory of Pediatrics Children's Hospital of Nanjing Medical University  Nanjing Jiangsu China"},{"name":"Department of Pediatrics Shandong University, Shandong Provincial Hospital  Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuzhen","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong China"},{"name":"Department of Pediatrics Shandong University, Shandong Provincial Hospital  Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,29]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"585","article-title":"Nrf2 signaling pathway: Pivotal roles in inflammation","volume":"2017","author":"Ahmed S. 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