{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:11:53Z","timestamp":1788412313172,"version":"build-2803163510"},"reference-count":49,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T00:00:00Z","timestamp":1703030400000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004748","name":"Mashhad University of Medical Sciences","doi-asserted-by":"publisher","award":["981873"],"award-info":[{"award-number":["981873"]}],"id":[{"id":"10.13039\/501100004748","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mental health disorders are linked to systemic inflammation. Due to high inflammation and mental health disorders in COVID\u201019 patients, we aimed to investigate the relationship between blood inflammatory markers such as red cell distribution width to platelet ratio (RPR), platelet\u2010lymphocyte ratio (PLR), neutrophil\/lymphocyte ratio (NLR), red cell distribution width (RDW), white blood cell (WBC), and psychological function in COVID\u201019 patients. In the current cross\u2010sectional study, neuro\u2010psychological function, and a complete blood count (CBC) were measured on 120 COVID\u201019 patients aged &gt;30\u2009years from the Imam Reza Hospital in Mashhad, Iran. Our results showed that anxiety related to MCHC (mean\u2009\u00b1\u2009SD: 32.71\u2009\u00b1\u20091.68, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), WBC (mean\u2009\u00b1\u2009SD: 12.23\u2009\u00b1\u20095.43, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), and PLR (median (IQR): 28.72 (15.88\u201341.31), <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) significantly. In the stress subgroup, only RPR was associated with stress (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Linear regression between hematological parameters and psychological score indicated that RDW and PLR had a significantly positive association with depression (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.086; <jats:italic>p<\/jats:italic>\u2009=\u20090.045 and <jats:italic>\u03b2<\/jats:italic>\u2009=\u20091.326; <jats:italic>p<\/jats:italic>\u2009=\u20090.016, respectively) and anxiety scores (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.100; <jats:italic>p<\/jats:italic>\u2009=\u20090.038 and <jats:italic>\u03b2<\/jats:italic>\u2009=\u20091.356; <jats:italic>p<\/jats:italic>\u2009=\u20090.010, respectively). Moreover, a positive correlation was found between PLR and stress (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20091.102; <jats:italic>p<\/jats:italic>\u2009=\u20090.012). This study showed a positive association between depression\/anxiety\/stress symptoms and levels of hematological inflammatory markers including PLR and RDW. The findings of this study provide novel insights into mental health and physiological markers, underscoring the potential influence of inflammation on mood disorders. Our findings offer exciting prospects for future research and may lead to innovative approaches in the management and treatment of depression, anxiety, and stress.<\/jats:p>","DOI":"10.14814\/phy2.15889","type":"journal-article","created":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T02:34:46Z","timestamp":1703126086000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The association of hematological inflammatory markers and psychological function in COVID\u201019 patients: A cross\u2010sectional study"],"prefix":"10.14814","volume":"11","author":[{"given":"Zahra","family":"Khorasanchi","sequence":"first","affiliation":[{"name":"Department of Nutrition, School of Medicine Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"Student Research Committee, Faculty of Medicine Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Rashidmayvan","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Food Sciences and Clinical Biochemistry, School of Medicine, Social Determinants of Health Research Center Gonabad University of Medical Science  Gonabad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elahe","family":"Hasanzadeh","sequence":"additional","affiliation":[{"name":"International UNESCO Center for Health Related Basic Sciences and Human Nutrition, Department of Nutrition, Faculty of Medicine Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Reza Shadmand Foumani","family":"Moghadam","sequence":"additional","affiliation":[{"name":"Nutrition Sciences Varastegan Institute for Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nafise","family":"Afkhami","sequence":"additional","affiliation":[{"name":"Departments of Biology, Faculty of Sciences, Mashhad Branch Islamic Azad University  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parisa","family":"Asadiyan\u2010Sohan","sequence":"additional","affiliation":[{"name":"Departments of Biology, Faculty of Sciences, Mashhad Branch Islamic Azad University  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Vahedi","family":"Fard","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Food Sciences and Clinical Biochemistry, School of Medicine, Social Determinants of Health Research Center Gonabad University of Medical Science  Gonabad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimia","family":"Mohammadhasani","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Food Sciences and Clinical Biochemistry, School of Medicine, Social Determinants of Health Research Center Gonabad University of Medical Science  Gonabad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naiemeh","family":"Varaste","sequence":"additional","affiliation":[{"name":"International UNESCO Center for Health Related Basic Sciences and Human Nutrition, Department of Nutrition, Faculty of Medicine Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Payam","family":"Sharifan","sequence":"additional","affiliation":[{"name":"Department of Nutrition, School of Medicine Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon","family":"Ferns","sequence":"additional","affiliation":[{"name":"Division of Medical Education Brighton and Sussex Medical School  Brighton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1081-6754","authenticated-orcid":false,"given":"Majid Ghayour","family":"Mobarhan","sequence":"additional","affiliation":[{"name":"International UNESCO Center for Health Related Basic Sciences and Human Nutrition, Department of Nutrition, Faculty of Medicine Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,20]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0260106020964981"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16883"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-019-01288-x"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-11-200"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2018.02.002"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(89)90047-4"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(88)90095-9"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/19932820.2021.2010337"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2012.07.006"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/08039488.2017.1363285"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.13037"},{"key":"e_1_2_13_13_1","article-title":"Hematologic parameters in patients with COVID\u201019 infection: A reply","volume":"95","author":"Fan B. E.","year":"2020","journal-title":"American Journal of Hematology"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir007"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10608-020-10143-y"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics10090618"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1348\/014466505X29657"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2020.01.001"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.5543\/tkda.2011.01578"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/02601060221082384"},{"key":"e_1_2_13_21_1","first-page":"6","article-title":"Psychological function and serum vitamin D concentration in COVID\u201019 patients: A cross\u2010sectional study","volume":"10","author":"Khorasanchi Z.","year":"2023","journal-title":"Reviews in Clinical Medicine"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000014834"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16794"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2018.04.023"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm-20-3989"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0233470"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0167000"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2020.07.034"},{"key":"e_1_2_13_29_1","volume-title":"Henry's clinical diagnosis and management by laboratory methods E\u2010book","author":"Mcpherson R. A.","year":"2021"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2016.146"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-010-0478-5"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-004-1014-5"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/34.5.601"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/08039488.2017.1340517"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glp163"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2005.06.001"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25767"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.61186\/najm.1.1.6"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2020.1060"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40795-021-00429-z"},{"key":"e_1_2_13_41_1","unstructured":"Sahebi A. Asghari M. J. &Salari R. S.(2005).Validation of depression anxiety and stress scale (DASS\u201021) for an Iranian population."},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.31782\/IJCRR.2021.13611"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.4306\/pi.2016.13.1.121"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3999(02)00456-7"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2020.110440"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1080\/17446651.2021.1909472"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.00170"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm-20-3391"},{"key":"e_1_2_13_49_1","first-page":"31","article-title":"Validity and reliability of the Iranian version of the insomnia severity index","volume":"19","author":"Yazdi Z.","year":"2012","journal-title":"The Malaysian Journal of Medical Sciences: Mjms"},{"key":"e_1_2_13_50_1","first-page":"5","article-title":"Ratio of neutrophil to lymphocyte counts\u2010rapid and simple parameter of systemic inflammation and stress in critically ill","volume":"102","author":"Zahorec R.","year":"2001","journal-title":"Bratislavske Lekarske Listy"}],"container-title":["Physiological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.15889","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T04:04:54Z","timestamp":1705377894000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.14814\/phy2.15889"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":49,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.14814\/phy2.15889"],"URL":"https:\/\/doi.org\/10.14814\/phy2.15889","archive":["Portico"],"relation":{},"ISSN":["2051-817X","2051-817X"],"issn-type":[{"value":"2051-817X","type":"print"},{"value":"2051-817X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"2023-08-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e15889"}}