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In the current study, we provide the first preclinical evidence demonstrating that although diet\u2010induced acute zinc deficiency (Zn\u2010D: ~50% decrease) did not worsen infection induced by either influenza A (H1N1) or methicillin\u2010resistant staph aureus (MRSA), Zn\u2010D mice were sensitive to the injurious effects of superinfection of H1N1 with MRSA. Although the mechanism underlying the sensitivity of ZnD mice to combined H1N1\/MRSA infection is unclear, it was noteworthy that this combination exacerbated lung injury as shown by lung epithelial injury markers (increased BAL protein) and decreased genes related to epithelial integrity in Zn\u2010D mice (surfactant protein C and secretoglobins family 1A member 1). As bacterial pneumonia accounts for 25%\u201350% of morbidity and mortality from influenza A infection, zinc deficiency may be an important pathology component of respiratory tract infections.<\/jats:p>","DOI":"10.14814\/phy2.15902","type":"journal-article","created":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T20:29:15Z","timestamp":1704140955000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Zinc deficiency enhances sensitivity to influenza A associated bacterial pneumonia in mice"],"prefix":"10.14814","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0959-5744","authenticated-orcid":false,"given":"Radha","family":"Gopal","sequence":"first","affiliation":[{"name":"Department of Pediatrics UPMC Children's Hospital of Pittsburgh  Pittsburgh Pennsylvania 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