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Quantitative computed tomography (QCT) along with data postprocessing is a useful tool to obtain detailed information on airway structure, parenchymal function, and computational flow features. In this study, we aim to identify the structural and functional differences between asthma with and without FAO. The FAO group was defined by a ratio of forced expiratory volume in 1\u2009s (FEV<jats:sub>1<\/jats:sub>) to forced vital capacity (FVC), FEV<jats:sub>1<\/jats:sub>\/FVC\u2009&lt;0.7. Accordingly, we obtained two sets of QCT images at inspiration and expiration of asthma subjects without (<jats:italic>N<\/jats:italic>\u2009=\u200924) and with FAO (<jats:italic>N<\/jats:italic>\u2009=\u200912). Structural and functional QCT\u2010derived airway variables were extracted, including normalized hydraulic diameter, normalized airway wall thickness, functional small airway disease, and emphysema percentage. A one\u2010dimensional (1D) computational fluid dynamics (CFD) model considering airway deformation was used to compare the pressure distribution between the two groups. The computational pressures showed strong correlations with the pulmonary function test (PFT)\u2010based metrics. In conclusion, asthma participants with FAO had worse lung functions and higher\u2010pressure drops than those without FAO.<\/jats:p>","DOI":"10.14814\/phy2.15909","type":"journal-article","created":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T01:26:53Z","timestamp":1704677213000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Structural and functional features of asthma participants with fixed airway obstruction using CT imaging and 1D computational fluid dynamics: A feasibility study"],"prefix":"10.14814","volume":"12","author":[{"given":"Quoc Hung","family":"Nguyen","sequence":"first","affiliation":[{"name":"School of Mechanical Engineering Kyungpook National University Daegu South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So Ri","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine and Allergy, Department of Internal Medicine Research Institute of Clinical Medicine of Jeonbuk National University\u2013Biomedical Research Institute of Jeonbuk National University Hospital Jeonju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kum Ju","family":"Chae","sequence":"additional","affiliation":[{"name":"Department of Radiology Research Institute of Clinical Medicine of Jeonbuk National University\u2013Biomedical Research Institute of Jeonbuk National University Hospital Jeonju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gong Yong","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Radiology Research Institute of Clinical Medicine of Jeonbuk National University\u2013Biomedical Research Institute of Jeonbuk National University Hospital Jeonju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5030-0296","authenticated-orcid":false,"given":"Sanghun","family":"Choi","sequence":"additional","affiliation":[{"name":"School of Mechanical Engineering Kyungpook National University Daegu South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2019.01.014"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI103715"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2018.00189"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40413-017-0153-4"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2021.109657"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.11.053"},{"issue":"1286","key":"e_1_2_8_8_1","first-page":"2015","article-title":"Quantitative assessment of multiscale structural and functional alterations in asthmatic populations","volume":"118","author":"Choi S.","year":"1985","journal-title":"Journal of Applied Physiology"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00280.2014"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00113.2013"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/6564854"},{"issue":"122","key":"e_1_2_8_12_1","first-page":"2019","article-title":"1D network simulations for evaluating regional flow and pressure distributions in healthy and asthmatic human lungs","volume":"127","author":"Choi S.","year":"1985","journal-title":"Journal of Applied Physiology"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00202013"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00082407"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01394.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2013.28.3.424"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.04.00051804"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2971"},{"key":"e_1_2_8_19_1","unstructured":"Global Initiative for Asthma.2022GINA report global strategy for asthma management and prevention2022."},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201908-1590ST"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.4.9807121"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1971.31.2.207"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1114\/1.1289457"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2017.03.012"},{"key":"e_1_2_8_25_1","article-title":"Dynamic flow characteristics in normal and asthmatic lungs. 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