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We sought to understand the role of IL\u201010 in the cross\u2010talk between these systems. Six\u2010week\u2010old IL\u201010 KO mice and their wild type (WT) counterparts were maintained on a standard rodent diet for 3 or 6\u2009months. Gene expression of proinflammatory markers and <jats:italic>Fgf23<\/jats:italic>, serum 17\u03b2\u2010estradiol (E2), and cardiac protein expression were assessed. Ileal <jats:italic>Il17a<\/jats:italic> and <jats:italic>Tnf<\/jats:italic> mRNA increased while <jats:italic>Il6<\/jats:italic> mRNA increased in the bone and heart by at least 2\u2010fold in IL\u201010 KO mice. Bone <jats:italic>Dmp1<\/jats:italic> and <jats:italic>Phex<\/jats:italic> mRNA were repressed at 6\u2009months in IL\u201010 KO mice, resulting in increased <jats:italic>Fgf23<\/jats:italic> mRNA (~4\u2010fold) that contributed to increased fibrosis. In the IL\u201010 KO mice, gut bacterial \u03b2\u2010glucuronidase activity and ovarian <jats:italic>Cyp19a1<\/jats:italic> mRNA were lower (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), consistent with reduced serum E2 and reduced cardiac pNOS3 (Ser<jats:sup>1119<\/jats:sup>) in these mice. Treatment of ileal lymphocytes with E2 reduced gut inflammation in WT but not IL\u201010 KO mice. In conclusion, our data suggest that diminished estrogen and defective bone mineralization increased FGF23 which contributed to cardiac fibrosis in the IL\u201010 KO mouse.<\/jats:p>","DOI":"10.14814\/phy2.15914","type":"journal-article","created":{"date-parts":[[2024,1,13]],"date-time":"2024-01-13T04:20:37Z","timestamp":1705119637000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Reduced estrogen signaling contributes to bone loss and cardiac dysfunction in interleukin\u201010 knockout mice"],"prefix":"10.14814","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9383-229X","authenticated-orcid":false,"given":"Sanmi E.","family":"Alake","sequence":"first","affiliation":[{"name":"Department of Nutritional Sciences Oklahoma State University  Stillwater Oklahoma 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