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Nineteen participants completed 5\u2009min of OLBNP and SSMs at driven frequencies of 0.05 and 0.10\u2009Hz across two visits. Autoregulatory plateaus were derived at both point\u2010estimates and across the cardiac cycle. Between\u2010day reliability was assessed with intraclass correlation coefficients (ICCs), Bland\u2013Altman plots with 95% limits of agreement (LOA), coefficient of variation (CoV), and smallest real differences. Construct validity between OLBNP\u2010SSMs were quantified with Bland\u2013Altman plots and Cohen's <jats:italic>d<\/jats:italic>. The expected autoregulatory curve with positive rising and negative falling slopes were present in only ~23% of the data. The between\u2010day reliability for the ICCs were poor\u2010to\u2010good with the CoV estimates ranging from ~50% to 70%. The 95% LOA were very wide with an average spread of ~450% for OLBNP and ~350% for SSMs. Plateaus were larger from SSMs compared to OLBNPs (moderate\u2010to\u2010large effect sizes). The cerebral pressure\u2010flow relationship is a complex regulatory process, and the \u201cblack\u2010box\u201d nature of this system can make it challenging to quantify. The current data reveals PPR analysis does not always elicit a clear\u2010cut central plateau with distinctive rising\/falling slopes.<\/jats:p>","DOI":"10.14814\/phy2.15919","type":"journal-article","created":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T01:58:13Z","timestamp":1706061493000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Validity and reliability of deriving the autoregulatory plateau through projection pursuit regression from driven methods"],"prefix":"10.14814","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9756-5793","authenticated-orcid":false,"given":"Joel S.","family":"Burma","sequence":"first","affiliation":[{"name":"Cerebrovascular Concussion Lab, Faculty of Kinesiology University of Calgary  Calgary Alberta Canada"},{"name":"Sport Injury Prevention Research Centre, Faculty of Kinesiology University of Calgary  Calgary Alberta Canada"},{"name":"Human Performance 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