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A computational model (CM) generated parameters quantifying ventricular\u2013vascular coupling, and pressure\u2013volume construct across levels of aortic compliance (C<jats:sub>A<\/jats:sub>). We studied how a loss from normal\u2010to\u2010stiff C<jats:sub>A<\/jats:sub> impacts critical care metrics of hemodynamics during vascular occlusion. Pulse pressure (PP), end\u2010systolic pressure (<jats:italic>P<\/jats:italic><jats:sub>es<\/jats:sub>), arterial compliance (Art\u2010ca), arterial elastance (Art\u2010ea), and dynamic arterial elastance (Eadyn), along mechanical efficiency (ME) were measured at five levels of C<jats:sub>A<\/jats:sub>. A loss in C<jats:sub>A<\/jats:sub> impacted all variables. During steady\u2010state conditions, PP, <jats:italic>P<\/jats:italic><jats:sub>es<\/jats:sub>, and stroke work increased significantly as C<jats:sub>A<\/jats:sub> decreased. Art\u2010ca decreased and Art\u2010ea increased similarly; Eadyn increased and ME decreased. During a decrease in preload across all C<jats:sub>A<\/jats:sub> levels, arterial dynamics measures remained linear. The CM demonstrated that a loss in C<jats:sub>A<\/jats:sub> impacts measures of arterial dynamics during steady\u2010state and transient conditions and the model demonstrates that critical care metrics are sensitive to changes in C<jats:sub>A<\/jats:sub>. While Art\u2010ca and Art\u2010ea were sensitive to changes in preload, Eadyn did not change.<\/jats:p>","DOI":"10.14814\/phy2.15920","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T01:50:29Z","timestamp":1706752229000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of <scp>ventricular\u2013vascular<\/scp> coupling with critical care metrics: An in silico approach"],"prefix":"10.14814","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1868-0150","authenticated-orcid":false,"given":"Lawrence J.","family":"Mulligan","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Cooper University Hospital  Camden New Jersey USA"},{"name":"Cooper Medical School of Rowan University  Camden New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin","family":"Ungerleider","sequence":"additional","affiliation":[{"name":"Cooper Medical School of Rowan University  Camden New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Friedman","sequence":"additional","affiliation":[{"name":"Cooper Medical School of Rowan University  Camden New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Sanders","sequence":"additional","affiliation":[{"name":"Cooper Medical School of Rowan University  Camden New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian","family":"Thrash","sequence":"additional","affiliation":[{"name":"North Dakota State University  Fargo North Dakota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Ewert","sequence":"additional","affiliation":[{"name":"University of North Dakota  Grand Forks North Dakota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludmil","family":"Mitrev","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Cooper University Hospital  Camden New Jersey USA"},{"name":"Cooper Medical School of Rowan University  Camden New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey C.","family":"Hill","sequence":"additional","affiliation":[{"name":"School of Medical Imaging and Therapeutics Massachusetts College of Pharmacy and Health Sciences University  Worcester Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,31]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00230.2014"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2021.05.057"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000000442"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(98)00374-X"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00923.2014"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2022.05.018"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.03696"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjpc\/zwad028"},{"issue":"2","key":"e_1_2_9_10_1","first-page":"H619","article-title":"Effects of increased afterload on left ventricular function in closed\u2010chest dogs","volume":"259","author":"Freeman G. 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