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One mechanism that may contribute to this heightened risk is an impairment in cerebrovascular carbon dioxide reactivity (CVR). We compared CVR between CKD patients stages III\u2013IV and controls (CON) without CKD but matched for hypertension and diabetes status. CVR was measured via 5% CO<jats:sub>2<\/jats:sub> inhalation followed by voluntary hyperventilation in 14 CKD and 11 CON participants while mean arterial pressure, end\u2010tidal carbon dioxide, and middle cerebral artery blood velocity (MCAv) were measured continuously. CVR was quantified as the linear relationship between etCO<jats:sub>2<\/jats:sub> and MCAv. We observed no difference in CVR between groups. Hypercapnic CVR: CKD\u2009=\u20091.2\u2009\u00b1\u20090.9\u2009cm\/s\/mm\u2009Hg, CON\u2009=\u20091.3\u2009\u00b1\u20090.8\u2009cm\/s\/mm\u2009Hg, hypocapnic CVR: CKD\u2009=\u20091.3\u2009\u00b1\u20090.9\u2009cm\/s\/mm\u2009Hg, CON\u2009=\u20091.5\u2009\u00b1\u20090.7\u2009cm\/s\/mm\u2009Hg, integrated CVR: CKD\u2009=\u20091.5\u2009\u00b1\u20091.1\u2009cm\/s\/mm\u2009Hg, CON\u2009=\u20091.7\u2009\u00b1\u20090.8\u2009cm\/s\/mm\u2009Hg, <jats:italic>p<\/jats:italic>\u2009\u2265\u20090.48. Unexpectedly, CVR was inversely related to estimated glomerular filtration rate in CKD (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.37, <jats:italic>p<\/jats:italic>\u2009=\u20090.02). We report that CVR remains intact in CKD and is inversely related to eGFR. These findings suggest that other mechanisms beyond CVR contribute to the elevated stroke risk observed in CKD.<\/jats:p>","DOI":"10.14814\/phy2.15998","type":"journal-article","created":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T02:24:06Z","timestamp":1712197446000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cerebrovascular carbon dioxide reactivity is intact in chronic kidney disease"],"prefix":"10.14814","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9782-1865","authenticated-orcid":false,"given":"Justin D.","family":"Sprick","sequence":"first","affiliation":[{"name":"Department of Kinesiology, Health Promotion and Recreation University of North Texas  Denton Texas 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Georgia USA"},{"name":"Research Service Line, Atlanta VA Health Care System  Decatur Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matias","family":"Zanuzzi","sequence":"additional","affiliation":[{"name":"Division of Renal Medicine, Department of Medicine Emory University School of Medicine  Atlanta Georgia USA"},{"name":"Research Service Line, Atlanta VA Health Care System  Decatur Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana","family":"DaCosta","sequence":"additional","affiliation":[{"name":"Division of Renal Medicine, Department of Medicine Emory University School of Medicine  Atlanta Georgia USA"},{"name":"Research Service Line, Atlanta VA Health Care System  Decatur Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanie","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Renal Medicine, Department of Medicine Emory University School of Medicine  Atlanta 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