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In desminopathy, inflammation affects muscle homeostasis and repair, and contributes to progressive muscle deterioration. Mitochondria morphology was also suggested to affect desminopathy progression. Epicatechin (Epi)\u2014a natural compound found in cacao\u2014has been proposed to regulate inflammatory signaling and mitochondria morphology in human and animal models. Hence, we hypothesize chronic Epi consumption to improve inflammatory pathway and mitochondria morphology in the peripheral blood mononuclear cells (PBMCs) of a desminopathy R350P patient. We found that 12\u2009weeks of Epi consumption partially restored TRL4 signaling, indicative of inflammatory signaling and mitochondria morphology in the desminopathy patient. Moreover, Epi consumption improved blood health parameters, including reduced HOMA\u2010IR and IL\u20106 levels in the desminopathy patient. This indicates that Epi consumption could be a useful tool to slow disease progression in desminopathy patients.<\/jats:p>","DOI":"10.14814\/phy2.16020","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T02:35:23Z","timestamp":1714012523000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of epicatechin consumption on the inflammatory pathway and mitochondria morphology in <scp>PBMC<\/scp> from a <scp>R350P<\/scp> desminopathy patient: A case report"],"prefix":"10.14814","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0587-1855","authenticated-orcid":false,"given":"Germ\u00e1n","family":"Tapia\u2010Curimil","sequence":"first","affiliation":[{"name":"Exercise Physiology and Metabolism Laboratory, School of Kinesiology, Faculty of Medicine Universidad Finis Terrae  Santiago Chile"},{"name":"Centro de Salud Deportiva Cl\u00ednica Santa Mar\u00eda  Santiago 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