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We aimed to compare the effect of exercise training and enalapril, an angiotensin\u2010converting enzyme inhibitor, on RAS modulation in the skeletal muscle of obese animals. Thus, we divided C57BL\/6 mice into two groups: standard chow (SC) and high\u2010fat (HF) diet for 16\u2009weeks. At the eighth week, the HF\u2010fed animals were divided into four subgroups\u2014sedentary (HF), treated with enalapril (HF\u2010E), exercise training protocol (HF\u2010T), and combined interventions (HF\u2010ET). After 8\u2009weeks of treatment, we evaluated body mass and index (BMI), body composition, exercise capacity, muscle morphology, and skeletal muscle molecular markers. All interventions resulted in lower BMI and attenuation of overactivation in the classical arm, while favoring the B2R in the bradykinin receptors profile. This was associated with reduced apoptosis markers in obese skeletal muscles. The HF\u2010T group showed an increase in muscle mass and expression of biosynthesis markers and a reduction in expression of degradation markers and muscle fiber atrophy due to obesity. These findings suggest that the combination intervention did not have a synergistic effect against obesity\u2010induced muscle remodeling. Additionally, the use of enalapril impaired muscle's physiological adaptations to exercise training.<\/jats:p>","DOI":"10.14814\/phy2.16025","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T01:28:45Z","timestamp":1714440525000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Obesity\u2010induced skeletal muscle remodeling: A comparative analysis of exercise training and ACE\u2010inhibitory drug in male mice"],"prefix":"10.14814","volume":"12","author":[{"given":"Ana Beatriz","family":"Proen\u00e7a","sequence":"first","affiliation":[{"name":"Laboratory of Exercise Sciences, Biomedical Institute Fluminense Federal University  Niteroi Rio de Janeiro Brazil"},{"name":"Research Center on Morphology and Metabolism, Biomedical Institute Fluminense Federal University  Niteroi Rio de Janeiro 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