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Blood velocities in the internal carotid artery (ICA), middle cerebral arteries (MCA, four subjects), and aorta were measured by Doppler ultrasound in 30\u00b0 and 60\u00b0 semi\u2010recumbent positions. ICA blood flow and CO were calculated. Arterial blood pressure (ABP, Finometer), and end\u2010tidal CO<jats:sub>2<\/jats:sub> (ETCO<jats:sub>2<\/jats:sub>) were recorded. ICA blood flow response was assessed by mixed\u2010models regression analysis. The synchronization index (SI) for the variable pairs ABP\u2013ICA blood velocity, ABP\u2013MCA velocities in 0.005\u20130.08\u2009Hz frequency interval was calculated as a measure of CA. Passive tilting from 30\u00b0 to 60\u00b0 resulted in 12% decrease in CO (<jats:italic>p<\/jats:italic>\u2009=\u20090.001); ICA blood flow tended to fall (<jats:italic>p<\/jats:italic>\u2009=\u20090.04); Resistance breathing restored CO and ICA blood flow despite a 10% ETCO<jats:sub>2<\/jats:sub> drop. ETCO<jats:sub>2<\/jats:sub> and CO contributed to ICA blood flow variance (adjusted <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>: 0.9, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). The median SI was low (&lt;0.2) indicating intact CA, confirmed by surrogate date testing. The peak SI was transiently elevated during resistance breathing in the 60\u00b0 position. Resistance breathing may transiently reduce CA efficiency. Paced breathing did not restore CO or ICA blood flow.<\/jats:p>","DOI":"10.14814\/phy2.16027","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T01:38:50Z","timestamp":1714441130000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Dynamic cerebral autoregulation is preserved during orthostasis and intrathoracic pressure regulation in healthy subjects: A pilot study"],"prefix":"10.14814","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7792-5907","authenticated-orcid":false,"given":"M.","family":"Skytioti","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine, Institute of Basic Medical Sciences University of Oslo  Oslo Norway"},{"name":"Department of Anesthesiology Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Wiedmann","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Sorteberg","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Romundstad","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Hassan\u00a0Ali","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Institute of Basic Medical Sciences University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Mohammad\u00a0Ayoubi","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Institute of Basic Medical Sciences University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Zilakos","sequence":"additional","affiliation":[{"name":"Light Structures AS  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Elstad","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Institute of Basic Medical Sciences University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,29]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1109\/RBME.2015.2436978"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.182667"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-022-01484-5"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6579\/aa638c"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2005.030262"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1006\/bulm.1998.0047"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2014.081190"},{"key":"e_1_2_12_10_1","first-page":"1372","article-title":"Comments on Point:Counterpoint: Sympathetic activity does\/does not influence cerebral blood flow. 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