{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:54:30Z","timestamp":1791492870351,"version":"4.3.4"},"reference-count":46,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:00:00Z","timestamp":1718668800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Low\u2010load resistance exercise (LLRE) to failure can increase muscle mass, strength, endurance, and mitochondrial oxidative capacity (OXPHOS). However, the impact of adding blood flow restriction to low\u2010load resistance exercise (LLBFR) when matched for volume on these outcomes is incompletely understood. This pilot study examined the impact of 6\u2009weeks of single\u2010legged LLBFR and volume\u2010matched LLRE on thigh bone\u2010free lean mass, strength, endurance, and mitochondrial OXPHOS. Twenty (12 males and 8 females) untrained young adults (mean\u2009\u00b1\u2009SD; 21\u2009\u00b1\u20092\u2009years, 168\u2009\u00b1\u200911\u2009cm, 68\u2009\u00b1\u200912\u2009kg) completed 6\u2009weeks of either single\u2010legged LLBFR or volume\u2010matched LLRE. Participants performed four sets of 30, 15, 15, and 15 repetitions at 25% 1\u2010RM of leg press and knee extension with or without BFR three times per week. LLBFR increased knee extension 1\u2010RM, knee extension endurance, and thigh bone\u2010free lean mass relative to control (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). LLRE increased leg press and knee extension 1\u2010RM relative to control (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.012 and\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.054, respectively). LLRE also increased mitochondrial OXPHOS (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.047 (nonparametric)). Our study showed that LLBFR increased muscle strength, muscle endurance, and thigh bone\u2010free lean mass in the absence of improvements in mitochondrial OXPHOS. LLRE improved muscle strength and mitochondrial OXPHOS in the absence of improvements in thigh bone\u2010free lean mass or muscle endurance.\n                  <\/jats:p>","DOI":"10.14814\/phy2.16041","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T06:54:17Z","timestamp":1718693657000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Impact of low\u2010load resistance exercise with and without blood flow restriction on muscle strength, endurance, and oxidative capacity: A pilot study"],"prefix":"10.14814","volume":"12","author":[{"given":"Brett H.","family":"Davis","sequence":"first","affiliation":[{"name":"School of Kinesiology Louisiana State University  Baton Rouge Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Stampley","sequence":"additional","affiliation":[{"name":"School of Kinesiology Louisiana State University  Baton Rouge Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Granger","sequence":"additional","affiliation":[{"name":"School of Kinesiology Louisiana State University  Baton Rouge Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew C.","family":"Scott","sequence":"additional","affiliation":[{"name":"School of Kinesiology Louisiana State University  Baton Rouge Louisiana USA"},{"name":"Pennington Biomedical Research Center Louisiana State University  Baton Rouge Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy D.","family":"Allerton","sequence":"additional","affiliation":[{"name":"Pennington Biomedical Research Center Louisiana State University  Baton Rouge Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil M.","family":"Johannsen","sequence":"additional","affiliation":[{"name":"School of Kinesiology Louisiana State University  Baton Rouge 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