{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T16:25:59Z","timestamp":1791044759029,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T00:00:00Z","timestamp":1717545600000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004844","name":"National Cheng Kung University Hospital","doi-asserted-by":"publisher","award":["NCKUH\u20109902062"],"award-info":[{"award-number":["NCKUH\u20109902062"]}],"id":[{"id":"10.13039\/501100004844","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In posterior spine surgery, retractors exert pressure on paraspinal muscles, elevating intramuscular pressure and compromising blood flow, potentially causing muscle injury during ischemia\u2013reperfusion. Ginkgo biloba extract (EGb 761), known for its antioxidant and free radical scavenging properties and its role in treating cerebrovascular diseases, is investigated for its protective effects against muscle ischemia\u2013reperfusion injury in\u00a0vitro and in\u00a0vivo. Animals were randomly divided into the control group, receiving normal saline, and experimental groups, receiving varying doses of EGb761 (25\/50\/100\/200\u2009mg\/kg). A 2\u2010h hind limb tourniquet\u2010induced ischemia was followed by reperfusion. Blood samples collected pre\u2010ischemia and 24\u2009h post\u2010reperfusion, along with muscle tissue samples after 24\u2009h, demonstrated that EGb761 at 1000\u2009\u03bcg\/mL effectively inhibited IL\u20106 and TNF\u2010\u03b1 secretion in RAW 264.7 cells without cytotoxicity. EGb761 significantly reduced nitric oxide (NO) and malondialdehyde (MDA) levels, myeloperoxidase (MPO) activity, and increased glutathione (GSH) levels compared to the control after 24\u2009h. Muscle tissue sections revealed more severe damage in the control group, indicating EGb761's potential in mitigating inflammatory responses and oxidative stress during ischemia\u2013reperfusion injury, effectively protecting against muscle damage.<\/jats:p>","DOI":"10.14814\/phy2.16050","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T03:09:51Z","timestamp":1717643391000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Anti\u2010oxidative and anti\u2010inflammatory effects of Ginkgo biloba extract (<scp>EGb761<\/scp>) on hindlimb skeletal muscle ischemia\u2013reperfusion injury in rats"],"prefix":"10.14814","volume":"12","author":[{"given":"Liang\u2010Yi","family":"Chen","sequence":"first","affiliation":[{"name":"Neurophysiology Laboratory, Neurosurgical Service, Department of Surgery, National Cheng Kung University Hospital, College of Medicine National Cheng Kung University  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