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Morris water maze and passive avoidance tests and biochemical measurements were carried out.In Morris water maze, LPS prolonged time and distance for finding the platform. In probe trial, it diminished time spent and traveled distance in the target zone. Injection of 2 and 3\u2009mg\/kg of SNP overturned the effect of LPS. In passive avoidance task, LPS postponed entrance into darkroom and reduced time spent in light room and incremented time spent in darkroom in 3, 24, and 72\u2009h after electrical shock. All three doses of SNP restored the effects of LPS. Biochemical experiments confirmed that LPS elevated interleukin\u20106 and malondialdehyde concentration and declined total thiol content and superoxide dismutase and catalase activity in the hippocampus and cortex tissues. SNP particularly at a 3\u2009mg\/kg dose ameliorated LPS effects on these parameters.SNP attenuated memory disabilities resulting from LPS through modifying inflammation and boosting antioxidant defense.<\/jats:p>","DOI":"10.14814\/phy2.16053","type":"journal-article","created":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T02:44:48Z","timestamp":1716950688000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Sodium nitroprusside restored lipopolysaccharide\u2010induced learning and memory impairment in male rats via attenuating inflammation and oxidative stress"],"prefix":"10.14814","volume":"12","author":[{"given":"Zeinab","family":"Hosseini","sequence":"first","affiliation":[{"name":"Applied Biomedical Research Center Mashhad University of Medical Sciences Mashhad 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