{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T05:59:00Z","timestamp":1785563940117,"version":"3.56.0"},"reference-count":53,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2024,6,30]],"date-time":"2024-06-30T00:00:00Z","timestamp":1719705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000383","name":"Higher Education Funding Council for Wales","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000383","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000288","name":"Royal Society","doi-asserted-by":"publisher","award":["WM170007"],"award-info":[{"award-number":["WM170007"]}],"id":[{"id":"10.13039\/501100000288","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to identify risk factors for abdominal aortic aneurysm (AAA)\u00a0from the largest Welsh screening cohort to date. Patients were recruited from 1993 (to 2015) as part of the South East Wales AAA screening programme through general practitioners. Demographic data and risk factors were collected by means of a self\u2010report questionnaire. Statistical tests were performed to determine whether associations could be observed between AAA and potential risk factors. Odds ratios (OR) were also calculated for each of the risk factors identified. A total of 6879 patients were included in the study. Two hundred and seventy\u2010five patients (4.0%) presented with AAA, of which 16% were female and 84% were male. Patients with AAA were older than the (no AAA) control group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). The following risk factors were identified for AAA: family history of AAA (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001); history of vascular surgery (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), cerebrovascular accident (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), coronary heart disease (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), diabetes (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), medication (<jats:italic>p<\/jats:italic>\u2009=\u20090.0018), claudication (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), smoking history (<jats:italic>p<\/jats:italic>\u2009=\u20090.0001) and chronic obstructive pulmonary disorder (<jats:italic>p<\/jats:italic>\u2009=\u20090.0007). AAA is associated with classical vascular risk factors, in addition to other less\u2010well\u2010documented risk factors including previous vascular surgery. These findings have practical implications with the potential to improve future clinical screening of patients in order to reduce AAA mortality.<\/jats:p>","DOI":"10.14814\/phy2.16130","type":"journal-article","created":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T04:35:44Z","timestamp":1719808544000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A prospective longitudinal study of risk factors for abdominal aortic aneurysm"],"prefix":"10.14814","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1005-7038","authenticated-orcid":false,"given":"Benjamin S.","family":"Stacey","sequence":"first","affiliation":[{"name":"Neurovascular Research Laboratory, Faculty of Life Sciences and Education University of South Wales  Pontypridd UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun Seok","family":"Cho","sequence":"additional","affiliation":[{"name":"Neurovascular Research Laboratory, Faculty of Life Sciences and Education University of South Wales  Pontypridd UK"},{"name":"Department of Surgery Royal Free Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0598-3929","authenticated-orcid":false,"given":"Damien","family":"Lan\u00e9elle","sequence":"additional","affiliation":[{"name":"Neurovascular Research Laboratory, Faculty of Life Sciences and Education University of South Wales  Pontypridd UK"},{"name":"UNICAEN, CHU Caen Normandie, Vascular Medicine Unit, INSERM, COMETE  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Bashir","sequence":"additional","affiliation":[{"name":"Neurovascular Research Laboratory, Faculty of Life Sciences and Education University of South Wales  Pontypridd UK"},{"name":"Department of Surgery University Hospital Wales  Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian M.","family":"Williams","sequence":"additional","affiliation":[{"name":"Neurovascular Research Laboratory, Faculty of Life Sciences and Education University of South Wales  Pontypridd UK"},{"name":"Department of Surgery University Hospital Wales  Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael H.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Neurovascular Research Laboratory, Faculty of Life Sciences and Education University of South Wales  Pontypridd UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0498-7095","authenticated-orcid":false,"given":"Damian M.","family":"Bailey","sequence":"additional","affiliation":[{"name":"Neurovascular Research Laboratory, Faculty of Life Sciences and Education University of South Wales  Pontypridd UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.16.8.963"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2013.05.003"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a010245"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.077503"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800641102"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurpub\/14.4.343"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2013.12.007"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2009.01.041"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.18928"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.817619"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000245819.32762.cb"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.622"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.7134"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-1615"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.001926"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-016-3705-9"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech-2014-204920"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1401430"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2010.05.090"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2008.08.012"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.10.1425"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(03)00136-8"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0081260"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2013.10.104"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2011-200949"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)92087-7"},{"key":"e_1_2_11_28_1","unstructured":"NHS. (2011\u20132012).NHS Abdominal Aortic Aneurysm (AAA) Screening Programme: Annual Report."},{"key":"e_1_2_11_29_1","volume-title":"AAA screening: Information for health professionals","author":"NHS","year":"2013"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2009.03.007"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800760517"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.036966"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2014.10.023"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyu218"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2013.01.306"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2013.11.005"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp2108504"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800820821"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.117.3.684"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.030379"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.8984"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.8707"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30639-6"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2017.04.018"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2013.08.029"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-821X(05)80254-3"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2015.10.005"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2005.01.002"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2001.115801"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.08.050955"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(99)70049-2"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(99)70129-1"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwk063"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep25003"}],"container-title":["Physiological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.16130","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T09:06:12Z","timestamp":1721120772000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.14814\/phy2.16130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,30]]},"references-count":53,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.14814\/phy2.16130"],"URL":"https:\/\/doi.org\/10.14814\/phy2.16130","archive":["Portico"],"relation":{},"ISSN":["2051-817X","2051-817X"],"issn-type":[{"value":"2051-817X","type":"print"},{"value":"2051-817X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,30]]},"assertion":[{"value":"2024-04-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e16130"}}