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No systematic assessment has been made to test differences in RV response to pressure overload between rat strains. We compared RV adaptation to pulmonary trunk banding (PTB) in Wistar (W), Sprague Dawley (SD), and Fischer344 (F) rats by hemodynamic profiling focusing on diastolic function. Age\u2010matched male rat weanlings were randomized to sham surgery (W\u2010sham, <jats:italic>n<\/jats:italic>\u2009=\u20095; SD\u2010sham, <jats:italic>n<\/jats:italic>\u2009=\u20094; F\u2010sham, <jats:italic>n<\/jats:italic>\u2009=\u20094) or PTB (W\u2010PTB, <jats:italic>n<\/jats:italic>\u2009=\u20098; SD\u2010PTB, <jats:italic>n<\/jats:italic>\u2009=\u20098; F\u2010PTB, <jats:italic>n<\/jats:italic>\u2009=\u20098). RV function was evaluated after 5\u2009weeks by echocardiography, cardiac MRI, and invasive pressure\u2010volume measurements. PTB caused RV failure and increased RV systolic pressures four\u2010fold in all three PTB groups compared with sham. W\u2010 and SD\u2010PTB had a 2.4\u2010fold increase in RV end\u2010systolic volume index compared with sham, while F\u2010PTB rats were less affected. Diastolic and right atrial impairment were evident by increased RV end\u2010diastolic elastance, filling pressure, and E\/e' in PTB rats compared with sham, again F\u2010PTB the least affected. In conclusions, PTB caused RV failure with signs of diastolic dysfunction. Despite a similar increase in RV systolic pressure, F\u2010PTB rats showed less RV dilatation and a more preserved diastolic function compared with W\u2010 and SD\u2010PTB.<\/jats:p>","DOI":"10.14814\/phy2.16132","type":"journal-article","created":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T06:45:59Z","timestamp":1720766759000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Right ventricular diastolic adaptation to pressure overload in different rat strains"],"prefix":"10.14814","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1221-0115","authenticated-orcid":false,"given":"Julie S.","family":"Axelsen","sequence":"first","affiliation":[{"name":"Department of Cardiology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus 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