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Our aim was to explore sites of caspase\u20101\u2010related inflammation in alveolar hypoxia. Wild type (WT) mice were exposed to environmental hypoxia or room\u2010air, and organs were analyzed. Right heart catheterization was performed after 14\u2009days of alveolar hypoxia in WT mice and mice transplanted with WT or caspase\u20101<jats:sup>\u2212\/\u2212<\/jats:sup> bone marrow. Hypoxia induced leukocyte accumulation and increased caspase\u20101 protein in the lungs, not in other organs. WT mice transplanted with WT or caspase\u20101<jats:sup>\u2212\/\u2212<\/jats:sup> bone marrow showed no difference in pulmonary leukocyte accumulation or development of pulmonary hypertension after alveolar hypoxia. Caspase\u20101 and IL\u201018 were detected in bronchial epithelium in WT mice, and hypoxia induced IL\u201018 secretion from bronchial epithelial cells. IL\u201018 stimulation generated IL\u20106 mRNA in monocytes. Phosphorylated STAT3 was increased in hypoxic lungs, not in other organs. Alveolar hypoxia induces caspase\u20101 activation and leukocyte accumulation specific to the lungs, not in other organs. Caspase\u20101 activation and IL\u201018 secretion from bronchial epithelial cells might initiate hypoxia\u2010induced inflammation, leading to pulmonary hypertension.<\/jats:p>","DOI":"10.14814\/phy2.16143","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T01:08:43Z","timestamp":1721610523000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Alveolar hypoxia induces organ\u2010specific inflammasome\u2010related inflammation in male mouse lungs"],"prefix":"10.14814","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6401-7341","authenticated-orcid":false,"given":"Camilla","family":"Udjus","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine Oslo University Hospital Ullev\u00e5l and University of Oslo  Oslo Norway"},{"name":"Institute for Experimental Medical Research Oslo University Hospital Ullev\u00e5l and University of Oslo  Oslo Norway"},{"name":"Institute of Clinical Medicine University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bente","family":"Halvorsen","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine University of Oslo  Oslo Norway"},{"name":"Research Institute of Internal Medicine Oslo University Hospital Rikshospitalet and University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang Yi","family":"Kong","sequence":"additional","affiliation":[{"name":"Research Institute of Internal Medicine Oslo University Hospital Rikshospitalet and University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen Lund","family":"Sagen","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine University of Oslo  Oslo Norway"},{"name":"Research Institute of Internal Medicine Oslo University Hospital Rikshospitalet and University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marita","family":"Martinsen","sequence":"additional","affiliation":[{"name":"Institute for Experimental Medical Research Oslo University Hospital Ullev\u00e5l and University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuan","family":"Yang","sequence":"additional","affiliation":[{"name":"Research Institute of Internal Medicine Oslo University Hospital Rikshospitalet and University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Else Marit","family":"L\u00f8berg","sequence":"additional","affiliation":[{"name":"Department of Pathology Oslo University Hospital Ullev\u00e5l and University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geir","family":"Christensen","sequence":"additional","affiliation":[{"name":"Institute for Experimental Medical Research Oslo University Hospital Ullev\u00e5l and University of Oslo  Oslo Norway"},{"name":"Institute of Clinical Medicine University of Oslo  Oslo Norway"},{"name":"K.G. 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