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We recruited females during low hormone (<jats:italic>n<\/jats:italic>\u2009=\u200922) and high hormone (<jats:italic>n<\/jats:italic>\u2009=\u200922) phases, and males (<jats:italic>n<\/jats:italic>\u2009=\u200922). Participants self\u2010identified as NHB (<jats:italic>n<\/jats:italic>\u2009=\u200933) or NHW (<jats:italic>n<\/jats:italic>\u2009=\u200933). Participants were instrumented with two microdialysis fibers: (1) lactated Ringer's (control) and (2) 500\u2009nM BQ\u2010123 (ET<jats:sub>A<\/jats:sub>R antagonist). Local heating was used to elicit cutaneous vasodilation, and an infusion of 20\u2009mM\u2009L\u2010NAME to quantify NO\u2010dependent vasodilation. At control sites, NO\u2010dependent vasodilation was lowest in NHB males (46\u2009\u00b1\u200913 %NO) and NHB females during low hormone phases (47\u2009\u00b1\u200912 %NO) compared to all NHW groups. Inhibition of ET<jats:sub>A<\/jats:sub>R increased NO\u2010dependent vasodilation in NHB males (66\u2009\u00b1\u200913 %NO), in both groups of females during low hormone phases (NHW, control: 64\u2009\u00b1\u200912 %NO, BQ\u2010123: 85\u2009\u00b1\u200911 %NO; NHB, BQ\u2010123: 68\u2009\u00b1\u200913 %NO), and in NHB females during high hormone phases (control: 61\u2009\u00b1\u200911 %NO, BQ\u2010123: 83\u2009\u00b1\u20099 %NO). There was no effect for ET<jats:sub>A<\/jats:sub>R inhibition in NHW males or females during high hormone phases. These data suggest the effect of ET<jats:sub>A<\/jats:sub>R inhibition on NO\u2010dependent vasodilation is influenced by biological sex and racial identity.<\/jats:p>","DOI":"10.14814\/phy2.16149","type":"journal-article","created":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T10:38:54Z","timestamp":1721212734000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The effect of endothelin a receptor inhibition and biological sex on cutaneous microvascular function in non\u2010Hispanic Black and White young adults"],"prefix":"10.14814","volume":"12","author":[{"given":"Casey G.","family":"Turner","sequence":"first","affiliation":[{"name":"Department of Kinesiology and Health Georgia State University  Atlanta Georgia USA"},{"name":"Molecular Cardiology Research Institute Tufts Medical Center  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew J.","family":"Hayat","sequence":"additional","affiliation":[{"name":"School of Public Health Georgia State University  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey S.","family":"Otis","sequence":"additional","affiliation":[{"name":"Department of Kinesiology and Health Georgia State University  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arshed A.","family":"Quyyumi","sequence":"additional","affiliation":[{"name":"Emory Clinical Cardiovascular Research Institute Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4763-0208","authenticated-orcid":false,"given":"Brett J.","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Kinesiology and Health Georgia State University  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.00854"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00457.2021"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00126.2019"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.236398"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000130590.24107.D3"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02015-6"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.31.6.1235"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01397.2013"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.026797"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.82.5.1607"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00452.2021"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00784.2014"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00602.2021"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1752-8062.2011.00264.x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs0960261"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.80.3.829"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2019.04.020"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000023160.67766.F0"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP086776"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.13625"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000129087.81352.7A"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(91)90641-3"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2014.12.002"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2018.02.001"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.07.119"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.105.091728"},{"key":"e_1_2_10_28_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1096\/fasebj.2020.34.s1.09064","article-title":"Cortisol mediated ET\u20101 production during stress: Potential link to cardiovascular disease","volume":"34","author":"Lopez P. 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