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Despite this, the effect of antiparkinson medication on memory\u2010guided movements has not been elucidated. We evaluated the effect of antiparkinson medication on motor control during a memory\u2010guided reaching task with short and long retention delays in participants with PD and compared performance to age\u2010matched healthy control (HC) participants. Thirty\u2010two participants with PD completed the motor section of the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS\u2010UPDRS III) and performed a memory\u2010guided reaching task with two retention delays (0.5\u2009s and 5\u2009s) while on and off medication. Thirteen HC participants completed the MDS\u2010UPDRS III and performed the memory\u2010guided reaching task. In the task, medication increased movement velocity, decreased movement time, and decreased reaction time toward what was seen in the HC. However, movement amplitude and reaching error were unaffected by medication. Shorter retention delays increased movement velocity and amplitude, decreased movement time, and decreased error, but increased reaction times in the participants with PD and HC. Together, these results imply that antiparkinson medication is more effective at altering the neurophysiological mechanisms controlling movement velocity and reaction time compared with other aspects of movement control.<\/jats:p>","DOI":"10.14814\/phy2.16150","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T02:13:34Z","timestamp":1724984014000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Medication improves velocity, reaction time, and movement time but not amplitude or error during memory\u2010guided reaching in Parkinson's disease"],"prefix":"10.14814","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0641-0601","authenticated-orcid":false,"given":"Michael P.","family":"Trevarrow","sequence":"first","affiliation":[{"name":"Department of Physical Therapy and Human Movement Sciences Northwestern University  Chicago Illinois 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