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Therefore, the objective of the present study was to determine the effects of stroke on muscle mass, fiber size and shape, capillarization and oxidative capacity of the rat <jats:italic>m. extensor carpi radialis<\/jats:italic> (ECR) and <jats:italic>m. flexor carpi ulnaris<\/jats:italic> (FCU) after a photothrombotic stroke in the forelimb region of the primary sensorimotor cortex. The main observation of the present study was that 4\u2009weeks after induction of stroke there were no significant changes in muscle fiber size and shape. Although there was no significant capillary rarefaction, there was some evidence for remodeling of the capillary bed as reflected by a reduced heterogeneity of capillary spacing (<jats:italic>p<\/jats:italic>\u2009=\u20090.006) that may result in improved muscle oxygenation. In the ECR, but not in the FCU, this was accompanied by reduction in muscle fiber oxidative capacity as reflected by reduced optical density of sections stained for succinate dehydrogenase (<jats:italic>p<\/jats:italic>\u2009=\u20090.013). The reduced oxidative capacity and absence of significant capillary rarefaction resulted in a capillary to fiber ratio per unit of oxidative capacity that was higher after stroke in the ECR (<jats:italic>p<\/jats:italic>\u2009=\u20090.01), but not in the FCU. This suggests that at least during the early stages, stroke is not necessarily accompanied by muscle fiber atrophy, and that stroke\u2010induced reductions in oxidative capacity resulting in relative excess of capillarization are muscle specific.<\/jats:p>","DOI":"10.14814\/phy2.16153","type":"journal-article","created":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T10:49:32Z","timestamp":1721213372000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Stroke\u2010induced excess in capillarization relative to oxidative capacity in rats is muscle specific"],"prefix":"10.14814","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7399-4841","authenticated-orcid":false,"given":"Hans","family":"Degens","sequence":"first","affiliation":[{"name":"Department of Life Sciences Manchester Metropolitan University  Manchester UK"},{"name":"Institute of Sport Science and Innovations Lithuanian Sports University  Kaunas Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arjun","family":"Paudyal","sequence":"additional","affiliation":[{"name":"Department of Life Sciences Manchester Metropolitan University  Manchester UK"},{"name":"Department of Human Movement Sciences, Faculty of Behavioural and Movement Sciences Amsterdam Movement Sciences, Vrije Universiteit Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gert","family":"Kwakkel","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine Amsterdam Movement Sciences, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam  Amsterdam The Netherlands"},{"name":"Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"},{"name":"Department of Neurorehabilitation Amsterdam Rehabilitation Research Centre  Amsterdam The 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