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However, 2DUS echocardiography does not capture regional differences in cardiac contractility since it relies on planar images to estimate left ventricular (LV) geometry and global function. Thus, the current study was designed to evaluate the efficacy of a newly developed 4\u2010dimensional ultrasound (4DUS) method in detecting cardiac functional differences between two models of MI, permanent ligation (PL), and ischemia\/reperfusion (I\/R) in rats. We found that only 4DUS was able to detect LV global functional differences between the two models and that 4DUS\u2010derived surface area strain accurately detected infarcted regions within the myocardium that correlated well with histological infarct size analysis. We also found that 4DUS\u2010derived strain, which includes circumferential, longitudinal, and surface area strain, correlated with the peak positive of the first derivative of left ventricular pressure (+<jats:italic>dP<\/jats:italic>\/<jats:italic>dt<\/jats:italic><jats:sub>max<\/jats:sub>). In conclusion, 4DUS strain echocardiography effectively assesses myocardial mechanics following experimentally induced ischemia in rats and accurately estimates infarct size as early as 1\u2009day after injury. 4DUS also correlates well with +<jats:italic>dP<\/jats:italic>\/<jats:italic>dt<\/jats:italic><jats:sub>max<\/jats:sub>, a widely used marker of cardiac contractility.<\/jats:p>","DOI":"10.14814\/phy2.16159","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T04:45:24Z","timestamp":1721709924000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["4D ultrasound\u2010based strain assessment of cardiac dysfunction in male rats with reperfused and nonreperfused myocardial infarction"],"prefix":"10.14814","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1062-7109","authenticated-orcid":false,"given":"Ana C. 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