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Several substrains of SS rats exist that differ in their blood pressure phenotypes and salt sensitivity. The goal of this study was to investigate whether the John\u2010Rapp\u2010derived SS rat (SS\/Jr), which exhibits spontaneous hypertension on a low\u2010salt diet, presents with hallmarks of vascular dysfunction observed in another experimental model of hypertension independent of dietary salt, the spontaneously hypertensive rat (SHR). Endothelium\u2010intact aortic rings and mesenteric resistance arteries were isolated from low\u2010salt fed adult male SS\/Jr rats and SHRs, or their respective controls, for isometric wire myography. Vessels were challenged with cumulative concentrations of various vasoactive substances, in the absence or presence of nitric oxide synthase or cyclooxygenase inhibitors. Despite showing some differences in their responses to various vasoactive substances, both SS\/Jr rats and SHRs exhibited key features of vascular dysfunction, including endothelial dysfunction and hyperresponsiveness to vasocontractile agonists. In conclusion, this study provides evidence to support the utility of the SS\/Jr rat strain maintained on a low\u2010salt diet as a valid experimental model for vascular dysfunction, a key feature of human hypertension.<\/jats:p>","DOI":"10.14814\/phy2.16165","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T02:35:51Z","timestamp":1721874951000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Spontaneous vascular dysfunction in Dahl salt\u2010sensitive male rats raised without a high\u2010salt diet"],"prefix":"10.14814","volume":"12","author":[{"given":"Arturo","family":"Grano\u00a0de\u00a0Oro","sequence":"first","affiliation":[{"name":"Department of Physiology and Pharmacology, Center for Hypertension and Personalized Medicine University of Toledo, College of Medicine and Life Sciences  Toledo Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjana","family":"Kumariya","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Center for Hypertension and Personalized Medicine University of Toledo, College of Medicine and Life Sciences  Toledo Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blair","family":"Mell","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Center for Hypertension and Personalized Medicine University of Toledo, College of Medicine and Life Sciences  Toledo Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasenka","family":"Zubcevic","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Center for Hypertension and Personalized Medicine University of Toledo, College of Medicine and Life Sciences  Toledo Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bina","family":"Joe","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Center for Hypertension and Personalized Medicine University of Toledo, College of Medicine and Life Sciences  Toledo Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9494-8219","authenticated-orcid":false,"given":"Islam","family":"Osman","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Center for Hypertension and Personalized Medicine University of Toledo, College of Medicine and Life Sciences  Toledo Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/hy02t2.102793"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2011.82"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.19.3.290"},{"key":"e_1_2_10_5_1","first-page":"H1810","article-title":"Effect of dietary salt on arteriolar nitric oxide in striated muscle of normotensive rats","volume":"264","author":"Boegehold M. 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