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This study investigated the effects of neuromuscular electrical stimulation (NMES) during 5\u2009days of bed rest on retaining lower limb muscle mass and muscle function in healthy young and old participants. One leg received NMES of the quadriceps muscle (3\u2009\u00d7\u200930min\/day) (NMES), and the other served as a control (CON). Isometric quadriceps strength (MVC), rate of force development (RFD), lower limb lean mass, and muscle thickness were assessed pre\u2010and post\u2010intervention. Muscle thickness remained unaltered with NMES in young and increased in old following bed rest, while it decreased in CON legs. In old participants, mid\u2010thigh lean mass (MTLM) was preserved with NMES while decreased in CON legs. In the young, only a tendency to change with bed rest was detected for MTLM. MVC and early\u2010phase RFD decreased in young and old, irrespective of NMES. In contrast, late\u2010phase RFD was retained in young participants with NMES, while it decreased in young CON legs, and in the old, irrespective of NMES. NMES during short\u2010term bed rest preserved muscle thickness but not maximal muscle strength. While young and old adults demonstrated similar adaptive responses in preventing the loss of skeletal muscle thickness, RFD was retained in the young only.<\/jats:p>","DOI":"10.14814\/phy2.16166","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T02:39:21Z","timestamp":1724035161000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Five days of bed rest in young and old adults: Retainment of skeletal muscle mass with neuromuscular electrical stimulation"],"prefix":"10.14814","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0594-3553","authenticated-orcid":false,"given":"Sofie K.","family":"Hansen","sequence":"first","affiliation":[{"name":"Geriatric Research Unit Copenhagen University Hospital \u2010 Bispebjerg and Frederiksberg  Copenhagen Denmark"},{"name":"CopenAge, Copenhagen Center for Clinical age Research University of Copenhagen  Copenhagen 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D.","family":"Gr\u00f8nb\u00e6k","sequence":"additional","affiliation":[{"name":"Geriatric Research Unit Copenhagen University Hospital \u2010 Bispebjerg and Frederiksberg  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania W.","family":"Berry","sequence":"additional","affiliation":[{"name":"Geriatric Research Unit Copenhagen University Hospital \u2010 Bispebjerg and Frederiksberg  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla M.","family":"Olsen","sequence":"additional","affiliation":[{"name":"Geriatric Research Unit Copenhagen University Hospital \u2010 Bispebjerg and Frederiksberg  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Aagaard","sequence":"additional","affiliation":[{"name":"Department of Sport and Clinical Biomechanics University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars 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