{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T03:01:00Z","timestamp":1788836460019,"version":"build-2803163510"},"reference-count":64,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T00:00:00Z","timestamp":1723507200000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study aimed to evaluate the influence of combined intermittent fasting (IF) and high\u2010intensity interval training (HIIT) on morphology, caspase\u2010independent apoptosis signaling pathway, and myostatin expression in soleus and gastrocnemius (white portion) muscles from healthy rats. Sixty\u2010day\u2010old male Wistar rats (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200960) were divided into four groups: control (C), IF, high\u2010intensity\u2010interval training (T), and high\u2010intensity\u2010interval training and intermittent fasting (T\u2010IF). The C and T groups received\n                    <jats:italic>ad libitum<\/jats:italic>\n                    chow daily; IF and T\u2010IF received the same standard chow every other day. Animals from T and T\u2010IF underwent a HIIT protocol five times a week for 12\u2009weeks. IF reduced gastrocnemius mass and increased pro\u2010apoptotic proteins apoptosis\u2010inducing factor (AIF) and endonuclease G (EndoG) in soleus and cleaved\u2010to\u2010non\u2010cleaved PARP\u20101 ratio and myostatin expression in gastrocnemius white portion. HIIT increased AIF and apoptosis repressor with caspase recruitment domain expression in soleus and cleaved\u2010to\u2010total PARP\u20101 ratio in gastrocnemius muscle white portion. The combination of IF and HIIT reduced fiber cross\u2010sectional area in both muscles, increased EndoG and AIF expression, and decreased cleaved\u2010to\u2010non\u2010cleaved PARP\u20101 ratio in gastrocnemius muscle white portion. Muscle responses to IF and HIIT are directly impacted by the muscle fiber type composition and are modulated, at least in part, by myostatin and caspase\u2010independent apoptosis signaling.\n                  <\/jats:p>","DOI":"10.14814\/phy2.16181","type":"journal-article","created":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T22:34:43Z","timestamp":1723588483000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Impact of combined intermittent fasting and high\u2010intensity interval training on apoptosis and atrophy signaling in rat fast\u2010 and slow\u2010twitch muscles"],"prefix":"10.14814","volume":"12","author":[{"given":"Maria Lua M.","family":"Mendon\u00e7a","sequence":"first","affiliation":[{"name":"Striated Muscle Study Laboratory Federal University of Mato Grosso do Sul (UFMS) Campo Grande Mato Grosso do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna R.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Striated Muscle Study Laboratory Federal University of Mato Grosso do Sul (UFMS) Campo Grande Mato Grosso do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo B.","family":"Romanenghi","sequence":"additional","affiliation":[{"name":"Striated Muscle Study Laboratory Federal University of Mato Grosso do Sul (UFMS) Campo Grande Mato Grosso do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego S. D.","family":"Santos","sequence":"additional","affiliation":[{"name":"Striated Muscle Study Laboratory Federal University of Mato Grosso do Sul (UFMS) Campo Grande Mato Grosso do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wander F. O.","family":"Fili\u00fa","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, Food and Nutrition Federal University of Mato Grosso do Sul (UFMS) Campo Grande Mato Grosso do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luana Urbano","family":"Pagan","sequence":"additional","affiliation":[{"name":"Internal Medicine Department Botucatu Medical School, Sao Paulo State University (UNESP) Botucatu Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katashi","family":"Okoshi","sequence":"additional","affiliation":[{"name":"Internal Medicine Department Botucatu Medical School, Sao Paulo State University (UNESP) Botucatu Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina P.","family":"Okoshi","sequence":"additional","affiliation":[{"name":"Internal Medicine Department Botucatu Medical School, Sao Paulo State University (UNESP) Botucatu Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Juliano","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Stem Cell, Cell Therapy and Toxicological Genetics Research Centre (CeTroGen), School of Medicine (FAMED) Federal University of Mato Grosso do Sul (UFMS) Campo Grande Mato Grosso do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvio A.","family":"Oliveira\u2010Junior","sequence":"additional","affiliation":[{"name":"Striated Muscle Study Laboratory Federal University of Mato Grosso do Sul (UFMS) Campo Grande Mato Grosso do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9477-3386","authenticated-orcid":false,"given":"Paula F.","family":"Martinez","sequence":"additional","affiliation":[{"name":"Striated Muscle Study Laboratory Federal University of Mato Grosso do Sul (UFMS) Campo Grande Mato Grosso do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddh018"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2011.04.015"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/2193\u20101801\u20102\u2010532"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097\u20104598(199910)22:10<1350::AID\u2010MUS3>3.0.CO;2\u20108"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/130.7.1743"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10974\u2010015\u20109410\u20108"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.36660\/abc.20190349"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1556\/2060.2020.00020"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsams.2017.06.001"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.010389"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1123\/japa.2018\u20100309"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40279\u2010013\u20100029\u2010x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401400"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1999.277.2.R601"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118697"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1023\/b:mcbi.0000044397.32748.23"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/2211\u20105463.12965"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4557"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00950.2009"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014\u20105793(00)01731\u20102"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20102007\u2010973004"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00176.2006"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00601"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2017.06.002"},{"key":"e_1_2_10_26_1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.70252\/ULIC9262","article-title":"The effect of high intensity interval run training on cross\u2010sectional area of the vastus lateralis in untrained college students","volume":"10","author":"Estes R. 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