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Some species are targets of conservation and rehabilitation efforts; other populations are permanently housed under human care and may contribute to clinical and biomedical investigations. Veterinary medical care for species under human care, at times, may necessitate the use of general anesthesia for diagnostic and surgical indications. However, the unique physiologic and anatomic adaptations of one representative diving marine mammal, the bottlenose dolphin, present several challenges in providing ventilatory and cardiovascular support to maintain adequate organ perfusion under general anesthesia. The goal of this review is to highlight the unique cardiopulmonary adaptations of the completely aquatic bottlenose dolphin (<jats:italic>Tursiops truncatus<\/jats:italic>), and to identify knowledge gaps in our understanding of how those adaptations influence their physiology and pose potential challenges for sedation and anesthesia of these mammals.<\/jats:p>","DOI":"10.14814\/phy2.16183","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T03:29:16Z","timestamp":1725852556000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardiopulmonary adaptations of a diving marine mammal, the bottlenose dolphin: Physiology during anesthesia"],"prefix":"10.14814","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6356-3260","authenticated-orcid":false,"given":"Carolina R.","family":"Le\u2010Bert","sequence":"first","affiliation":[{"name":"Department of Physiology &amp; Aging, College of Medicine University of Florida  Gainesville Florida USA"},{"name":"U.S. Navy Marine Mammal Program Naval Information Warfare Center Pacific  San Diego California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordon S.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, College of Public Human and Health Professionals University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4074-9070","authenticated-orcid":false,"given":"Leah R.","family":"Reznikov","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences, College of Veterinary Medicine University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-090121-014424"},{"key":"e_1_2_7_3_1","unstructured":"Bailey J. 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