{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:12:03Z","timestamp":1789564323747,"version":"build-2803163510"},"reference-count":62,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:00Z","timestamp":1729641600000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Depression and anxiety are common mental health disorders affecting thoughts, behaviors, and emotions. This study aimed to investigate the effect of the angiotensin II type I receptor blocker (AT1RB), valsartan, on menopause\u2010induced depression and anxiety\u2010like behaviors, and to elucidate possible mechanisms of action by measuring levels of nod\u2010like receptor protein 3 (NLRP3), interleukin\u20101beta (IL\u20101\u03b2), brain\u2010derived neurotrophic factor (BDNF), and oxidative stress in brain tissue. Thirty\u2010two Wistar albino female rats were randomly divided into four groups (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20098 per group): Control, AT1RB, OVX, and AT1RB\u2009+\u2009OVX. Following the bilateral ovariectomy (OVX) protocol, physiological saline was used as valsartan solvent, in a maximum volume of 0.4\u2009mL, and valsartan was administered via intragastric gavage at a dose of 40\u2009mg\/kg\/day. Depression and anxiety\u2010like behaviors were assessed using the forced swimming test and open field test. Levels of oxidative stress markers, NLRP3, IL\u20101\u03b2, BDNF, and CREB were analyzed in the hippocampus and prefrontal cortex tissues. Behavioral tests indicated that depression and anxiety\u2010like behaviors significantly increased in OVX rats (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01), while AT1RB treatment significantly reduced these behaviors (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). In the hippocampus of OVX rats, oxidative stress (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01), NLRP3 (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05), and IL\u20101\u03b2 (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01) levels were elevated, whereas BDNF levels were significantly decreased (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01). AT1RB treatment significantly improved oxidative stress parameters (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) and BDNF levels (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01) but did not significantly affect the increased levels of NLRP3 and IL\u20101\u03b2 in OVX rats. In conclusion, AT1RB has a therapeutic effect on menopause\u2010induced depression and anxiety\u2010like behaviors, likely by reducing oxidative stress and increasing BDNF production in the hippocampus.\n                  <\/jats:p>","DOI":"10.14814\/phy2.70003","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T21:59:25Z","timestamp":1729720765000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The protective effect of angiotensin\n                    <scp>II<\/scp>\n                    type I receptor blocker (valsartan) on behavioral impairment,\n                    <scp>NLRP3<\/scp>\n                    ,\n                    <scp>BDNF<\/scp>\n                    , and oxidative stress in the brain tissue of ovariectomized female rats"],"prefix":"10.14814","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3277-0539","authenticated-orcid":false,"given":"Salih","family":"Erdem","sequence":"first","affiliation":[{"name":"Ahmet Erdo\u011fan Vocational School of Health Services, Pathology Program Zonguldak B\u00fclent Ecevit University  Zonguldak Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3564-0468","authenticated-orcid":false,"given":"Hale Sayan","family":"\u00d6za\u00e7mak","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine Zonguldak B\u00fclent Ecevit University  Zonguldak Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2211-3914","authenticated-orcid":false,"given":"\u0130nci","family":"Turan","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine Zonguldak B\u00fclent Ecevit University  Zonguldak Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0628-4791","authenticated-orcid":false,"given":"Meryem","family":"Ergen\u00e7","sequence":"additional","affiliation":[{"name":"Ahmet Erdo\u011fan Vocational School of Health Services, Anesthesia Program Zonguldak B\u00fclent Ecevit University  Zonguldak Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,23]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2016.10.026"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2018.09.027"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1590\/1516\u20104446\u20102013\u20101098"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/S2045796022000439"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.21518\/2079\u2010701X\u20102022\u201016\u201016\u2010124\u2010129"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300\u2010483X(85)90008\u20103"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201500338"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2010.225"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010015\u20109584\u20105"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1017\/S003329171100016X"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.161.4.598"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571\u2010019\u201000744\u2010x"},{"key":"e_1_2_12_14_1","first-page":"520","article-title":"Lipid peroxidation and cellular damage in extrahepatic tissues of bromobenzene\u2010intoxicated mice","volume":"123","author":"Casini A. 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