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We hypothesized ET receptor antagonism would lower resting blood pressure (BP) as well as the acute BP response to chemoreflex stress. Twenty\u2010four men (31\u2009\u00b1\u20095\u2009years, 26\u2009\u00b1\u20093\u2009kg\/m<jats:sup>2<\/jats:sup>) completed two study visits (control, bosentan). On each visit, BP was assessed under three conditions: (1) normoxia (F<jats:sub>i<\/jats:sub>O<jats:sub>2<\/jats:sub> 0.21), (2) chemoreflex excitation via hypoxia (F<jats:sub>i<\/jats:sub>O<jats:sub>2<\/jats:sub> 0.05\u20130.21), (3) chemoreflex inhibition via hyperoxia (F<jats:sub>i<\/jats:sub>O<jats:sub>2<\/jats:sub> 1.00). Bosentan increased plasma ET\u20101 (0.94\u2009\u00b1\u20090.90 to 1.27\u2009\u00b1\u20090.62\u2009pg\/mL, <jats:italic>p<\/jats:italic>\u2009=\u20090.004), supporting receptor blockade. Resting diastolic (73\u2009\u00b1\u20095 to 69\u2009\u00b1\u20097\u2009mmHg, <jats:italic>p<\/jats:italic>\u2009=\u20090.007) and mean (93\u2009\u00b1\u20097 to 88\u2009\u00b1\u20097\u2009mmHg, <jats:italic>p<\/jats:italic>\u2009=\u20090.005) BP were reduced following bosentan compared to control with no change in systolic BP (<jats:italic>p<\/jats:italic>\u2009=\u20090.507). The mean BP response to both acute hypoxia (\u22120.48\u2009\u00b1\u20090.38 to \u22120.25\u2009\u00b1\u20090.31\u2009mmHg\/%, <jats:italic>p<\/jats:italic>\u2009=\u20090.004) and hyperoxia (area under the curve \u221293\u2009\u00b1\u2009108 to \u221227\u2009\u00b1\u200966\u2009AU, <jats:italic>p<\/jats:italic>\u2009=\u20090.018) were attenuated following bosentan. Acute ET receptor inhibition attenuates the rise in BP during chemoreflex excitation as well as the fall in BP during chemoreflex inhibition in healthy young men. These data support a role for ET\u20101 in control of resting BP, possibly through a chemoreceptor\u2010mediated mechanism.<\/jats:p>","DOI":"10.14814\/phy2.70004","type":"journal-article","created":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T00:54:53Z","timestamp":1725238493000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of endothelin\u20101 on the blood pressure response to acute hypoxia and hyperoxia in healthy young men"],"prefix":"10.14814","volume":"12","author":[{"given":"Anna M.","family":"Gonsalves","sequence":"first","affiliation":[{"name":"Department of Nutrition and Exercise Physiology University of Missouri  Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Baker","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dain W.","family":"Jacob","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Exercise Physiology University of Missouri  Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Harper","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Exercise Physiology University of Missouri  Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila M.","family":"Manrique\u2010Acevedo","sequence":"additional","affiliation":[{"name":"Dalton Cardiovascular Research Center University of Missouri  Columbia Missouri USA"},{"name":"Department of Medicine University of Missouri  Columbia Missouri USA"},{"name":"Research Service Harry S. 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