{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T15:07:55Z","timestamp":1785856075864,"version":"3.56.0"},"reference-count":30,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T00:00:00Z","timestamp":1724284800000},"content-version":"am","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T00:00:00Z","timestamp":1724284800000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009898","name":"Defense Health Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009898","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006229","name":"Oak Ridge Institute for Science and Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006229","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The objective of this study was to examine the effect of consuming ketone monoester plus a high dose of carbohydrate from glucose (KE\u2009+\u2009CHO) on the change in erythropoietin (EPO) concentrations during load carriage exercise compared with carbohydrate (CHO) alone. Using a randomized, crossover design, 12 males consumed KE\u2009+\u2009CHO (573\u2009mg KE\/kg body mass, 110\u2009g glucose) or CHO (110\u2009g glucose) 30\u2009min before 4\u2009miles of self\u2010paced treadmill exercise (KE\u2009+\u2009CHO:51\u2009\u00b1\u200913%, CHO: 52\u2009\u00b1\u200912% V\u0307O<jats:sub>2peak<\/jats:sub>) wearing a weighted vest (30% body mass; 25\u2009\u00b1\u20093\u2009kg). Blood samples for analysis were obtained under resting fasted conditions before (Baseline) consuming the KE\u2009+\u2009CHO or CHO supplement and immediately after exercise (Post). \u03b2HB increased (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) from Baseline to Post in KE\u2009+\u2009CHO, with no change in CHO. Glucose and glycerol increased (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) from Baseline to Post in CHO, with no effect of time in KE\u2009+\u2009CHO. Insulin and lactate increased (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) from Baseline to Post independent of treatment. EPO increased (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) from Baseline to Post in KE\u2009+\u2009CHO and CHO with no difference between treatments. Although KE\u2009+\u2009CHO altered \u03b2HB, glucose, and glycerol concentrations, results from this study suggest that KE\u2009+\u2009CHO supplementation before load carriage exercise does not enhance immediate post\u2010exercise increases in EPO compared with CHO alone.<\/jats:p>","DOI":"10.14814\/phy2.70009","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T03:20:46Z","timestamp":1724383246000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Ketone monoester plus high\u2010dose glucose supplementation before exercise does not affect immediate post\u2010exercise erythropoietin concentrations versus glucose alone"],"prefix":"10.14814","volume":"12","author":[{"given":"Emily E.","family":"Howard","sequence":"first","affiliation":[{"name":"Military Nutrition Division U.S. Army Research Institute of Environmental Medicine (USARIEM)  Natick Massachusetts 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Research Institute of Environmental Medicine (USARIEM)  Natick Massachusetts USA"},{"name":"Oak Ridge Institute for Science and Education  Belcamp Maryland USA"},{"name":"Faculty of Kinesiology &amp; Physical Education University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin S.","family":"O'Fallon","sequence":"additional","affiliation":[{"name":"Soldier Effectiveness Directorate U.S. Army Combat Capabilities Development Command Soldier Center  Natick Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0652-1304","authenticated-orcid":false,"given":"Lee M.","family":"Margolis","sequence":"additional","affiliation":[{"name":"Military Nutrition Division U.S. Army Research Institute of Environmental Medicine (USARIEM)  Natick Massachusetts 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