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While enhanced responsivity to repeated exposures of muscle contractions have been documented for Snell dwarf mice, the response following single exposure to distinct contraction protocols remained uncharacterized. The purpose of this study was to investigate the muscle recovery of Snell dwarf and control littermate mice following a single exposure to two separate protocols\u2014an intermittent slow velocity (30\u00b0\/s) contraction protocol or a continuous rapid velocity (500\u00b0\/s) contraction protocol. Following both protocols for control mice, torque values were 30% and 80% of pre\u2010protocol values at 5\u2009min and 3\u2009days, respectively. At 10\u2009days, performance returned to baseline for the 30\u00b0\/s protocol and were depressed for the 500\u00b0\/s protocol. For Snell dwarf mice following both protocols, torques were depressed to 5% of pre\u2010protocol values at 5\u2009min and returned to baseline by 3\u2009days. Recovery following the 30\u00b0\/s protocol for control mice and both protocols for Snell dwarf mice coincided with increased transcriptional output, upregulation of cytokine\u2010mediated signaling genes, and a distribution shift to smaller muscle fibers with reduced area per nucleus. These features represent efficacious remodeling ubiquitous across distinct contraction paradigms in the context of the<jats:italic>Pit1<\/jats:italic>mutation.<\/jats:p>","DOI":"10.14814\/phy2.70027","type":"journal-article","created":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T02:49:14Z","timestamp":1725418154000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Transcriptional and morphological responses following distinct muscle contraction protocols for Snell dwarf (<i>Pit1<sup>dw\/dw<\/sup><\/i>) mice"],"prefix":"10.14814","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7538-0261","authenticated-orcid":false,"given":"Erik P.","family":"Rader","sequence":"first","affiliation":[{"name":"Centers for Disease Control and Prevention National Institute for Occupational Safety and Health Morgantown West Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly A.","family":"McKinstry","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention National Institute for Occupational Safety and Health Morgantown West Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brent A.","family":"Baker","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention National Institute for Occupational Safety and Health Morgantown West Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqac198"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.888464"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072255"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1992.72.3.1205"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.12976"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1139\/h05\u2010009"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glab147"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00428.2023"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10974\u2010022\u201009617\u20101"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000002126"},{"issue":"4","key":"e_1_2_11_12_1","first-page":"332","article-title":"Drop jumping. 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