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Few studies assess postural effects, but less investigate relationships between age and NVC within different postures. Therefore, this study investigated the effect of age on NVC in different postures with varying cognitive stimuli. Beat\u2010to\u2010beat blood pressure, heart rate and end\u2010tidal carbon dioxide were assessed alongside middle and posterior cerebral artery velocities (MCAv and PCAv, respectively) using transcranial Doppler ultrasonography in 78 participants (31 young\u2010, 23 middle\u2010 and 24 older\u2010aged) with visuospatial (VST) and attention tasks (AT) in various postures at two timepoints (T2 and T3). Between\u2010group significance testing utilized one\u2010way analysis\u2010of\u2010variance (ANOVA) (Tukey post\u2010hoc). Mixed three\u2010way\/one\u2010way ANOVAs explored task, posture, and age interactions. Significant effects of posture on NVC were driven by a 3.8% increase from seated to supine. For AT, mean supine %MCAv increase was greatest in younger (5.44%) versus middle (0.12%) and older\u2010age (0.09%) at T3 (<jats:italic>p<\/jats:italic>\u2009=\u20090.005). For VST, mean supine %PCAv increase was greatest at T2 and T3 in middle (10.99%\/10.12%) and older\u2010age (17.36%\/17.26%) versus younger (9.44%\/8.89%) (<jats:italic>p<\/jats:italic>\u2009=\u20090.004\/<jats:italic>p<\/jats:italic>\u2009=\u20090.002). We identified significant age\u2010related NVC effects with VST\u2010induced hyperactivation. This may reflect age\u2010related compensatory processes in supine. Further work is required, using complex stimuli while standing\/walking, examining NVC, aging and falls.<\/jats:p>","DOI":"10.14814\/phy2.70031","type":"journal-article","created":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T01:09:13Z","timestamp":1725239353000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The effect of posture on the age dependence of neurovascular coupling"],"prefix":"10.14814","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9174-6988","authenticated-orcid":false,"given":"James D.","family":"Ball","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Sciences University of Leicester  Leicester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron","family":"Davies","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences University of Leicester  Leicester 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