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Minocycline, recognized for its potent anti\u2010inflammatory properties, was investigated in this study for its protective effects against sepsis\u2010induced brain injury. Adult male C57 mice pretreated with minocycline (12.5, 25, and 50\u2009mg\/kg) 3\u2009days before sepsis induction. An intraperitoneal injection of 5\u2009mg\/kg LPS was used to induce sepsis. Spontaneous locomotor activity (SLA) and weight changes were assessed over several days post\u2010sepsis to monitor the recovery of the mice. The expression of inflammatory mediators and oxidative stress markers was assessed 24\u2009h post sepsis. Septic mice exhibited significant weight loss and impaired SLA. Initially, minocycline did not attenuate the severity of weight loss (1\u2009day) or SLA (4\u2009h post\u2010sepsis), but it significantly accelerated the recovery of the mice in later days. Minocycline dose\u2010dependently mitigated sepsis\u2010induced brain inflammation and oxidative stress. Our findings demonstrate that pretreatment with minocycline has the potential to prevent brain tissue damage and accelerate recovery from sepsis in mice, suggesting that minocycline may serve as a promising therapeutic intervention to protect against sepsis\u2010induced neurological complications.<\/jats:p>","DOI":"10.14814\/phy2.70032","type":"journal-article","created":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T01:09:37Z","timestamp":1728263377000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Minocycline mitigates sepsis\u2010induced neuroinflammation and promotes recovery in male mice: Insights into neuroprotection and inflammatory modulation"],"prefix":"10.14814","volume":"12","author":[{"given":"Mahmoud","family":"Hosseini","sequence":"first","affiliation":[{"name":"Psychiatry and Behavioral Sciences Research Center Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"Applied Biomedical 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