{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T01:17:41Z","timestamp":1788484661133,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2024,10,13]],"date-time":"2024-10-13T00:00:00Z","timestamp":1728777600000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Hypotension is one of the main characteristics of the systemic inflammation, basically caused by endothelial dysfunction. Studies have shown that the amino acid L\u2010kynurenine (KYN) causes vasodilation in mammals, leading to hypotensive shock. In hypotensive shock, when activated by the KYN, the voltage\u2010gated potassium channel encoded by the family\n                    <jats:italic>KCNQ<\/jats:italic>\n                    (Kv7) gene can cause vasodilation. Fructose\u20101,6\u2010bisphosphate (FBP) it is being considered in studies an anti\u2010inflammatory, antioxidant, immunomodulator, and a modulator of some ion channels (Ca2+, Na+, and K+). We analyzed the effects of KYN and FBP on mean blood pressure (MBP), systolic and diastolic (DBP) blood pressure, and heart rate variability (HRV) in\n                    <jats:italic>Wistar<\/jats:italic>\n                    rats. Results demonstrated that the administration of KYN significant decreased MBP, DBP, and increased HRV. Importantly, the FBP treatment reversed the KYN effects on MBP, DBP, and HRV. Molecular Docking Simulations suggested that KYN and FBP present a very close estimated free energy of binding and the same position into structure of\n                    <jats:italic>KCNQ4<\/jats:italic>\n                    . Our results did demonstrate that FBP blunted the decrease in BP, provoked by KYN. Results raise new hypotheses for future and studies in the treatment of hypotension resulting from inflammation.\n                  <\/jats:p>","DOI":"10.14814\/phy2.70033","type":"journal-article","created":{"date-parts":[[2024,10,13]],"date-time":"2024-10-13T22:39:49Z","timestamp":1728859189000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Fructose\u20101,6\u2010bisphosphate reverses hypotensive effect caused by L\u2010kynurenine in\n                    <i>Wistar<\/i>\n                    male rats"],"prefix":"10.14814","volume":"12","author":[{"given":"Anderson Velasque","family":"Catarina","sequence":"first","affiliation":[{"name":"Graduate Program in Pathology\u2014Laboratory of Computational Molecular, and Cellular Biophysics\u2014Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre (UFCSPA)  Porto Alegre 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