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In this study, we explored changes in anabolic processes in both skeletal and cardiac muscles in the Yoshida AH\u2010130 ascites hepatoma model of cancer cachexia. AH\u2010130 tumor\u2010bearing rats experienced significant losses in body weight, skeletal muscle, and heart mass. Skeletal and cardiac muscle loss was associated with decreased ribosomal (r)RNA, and hypophosphorylation of the eukaryotic factor 4E binding protein 1. Endoplasmic reticulum stress was evident by higher activating transcription factor mRNA in skeletal muscle and growth arrest and DNA damage\u2010inducible protein (GADD)34 mRNA in both skeletal and cardiac muscles. Tumors provoked an increase in tissue expression of interferon\u2010\u03b3 in the heart, while an increase in interleukin\u20101\u03b2 mRNA was apparent in both skeletal and cardiac muscles. We conclude that compromised skeletal muscle and heart mass in the Yoshida AH\u2010130 ascites hepatoma model involves a marked reduction translational capacity and efficiency. Furthermore, our observations suggest that endoplasmic reticulum stress and tissue production of pro\u2010inflammatory factors may play a role in the development of skeletal and cardiac muscle wasting.<\/jats:p>","DOI":"10.14814\/phy2.70044","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T03:43:58Z","timestamp":1726717438000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Anabolic deficits and divergent unfolded protein response underlie skeletal and cardiac muscle growth impairments in the Yoshida hepatoma tumor model of cancer cachexia"],"prefix":"10.14814","volume":"12","author":[{"given":"Daniel J.","family":"Belcher","sequence":"first","affiliation":[{"name":"Huck Institutes of the Life Sciences The Pennsylvania State University  University Park Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Kinesiology The Pennsylvania State University  University Park Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanca","family":"Navarro\u2010Llinas","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Medicine University of Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"M\u00f6ller","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Medicine University of Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco J.","family":"L\u00f3pez\u2010Soriano","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Medicine University of Barcelona  Barcelona Spain"},{"name":"Institut de Biomedicina de la Universitat de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Busquets","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Medicine University of Barcelona  Barcelona Spain"},{"name":"Institut de Biomedicina de la Universitat de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2220-4296","authenticated-orcid":false,"given":"Gustavo A.","family":"Nader","sequence":"additional","affiliation":[{"name":"Huck Institutes of the Life Sciences The Pennsylvania State University  University Park Pennsylvania USA"},{"name":"Department of Kinesiology The Pennsylvania State University  University Park Pennsylvania USA"},{"name":"Penn State Cancer Institute The Pennsylvania State University  University Park Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3829"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1995.268.5.E996"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.105"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.12184"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2005.02.017"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00246.2022"},{"key":"e_1_2_10_8_1","first-page":"4149","article-title":"Changes in nucleic acid and protein levels in atrophying skeletal muscle in cancer cachexia","volume":"26","author":"Bhogal A. 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