{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:11:04Z","timestamp":1753884664964,"version":"3.41.2"},"reference-count":50,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T00:00:00Z","timestamp":1725926400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019875","name":"NxStage","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/100019875","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>People with end\u2010stage kidney disease (ESKD) often exhibit impaired cardiac structure and function, which may contribute to poor exercise capacity. This study used multimodal exercise testing to investigate the central and peripheral mechanisms of exercise limitation in adults with ESKD, also comparing in\u2010centre hemodialysis (ICHD) to home hemodialysis (HHD). Seventeen adults (55.5\u2009\u00b1\u200914.5\u2009years; <jats:italic>n<\/jats:italic>\u2009=\u200914 male; <jats:italic>n<\/jats:italic>\u2009=\u200912 HHD) participated. Resting cardiac examinations, followed by submaximal cycling cardiopulmonary exercise testing (CPET) and functional exercise testing, revealed cardiac structural abnormalities (increased left ventricular mass) and cardiac injury. Aerobic fitness in adults with ESKD was low, with pulmonary oxygen uptake (V\u0307O<jats:sub>2<\/jats:sub>) at the gas exchange threshold (GET) occuring at 39\u2009\u00b1\u20098% predicted V\u0307O<jats:sub>2peak<\/jats:sub>. O<jats:sub>2<\/jats:sub> pulse, an estimate of stroke volume (SV), was higher in HHD at rest (<jats:italic>p<\/jats:italic>\u2009=\u20090.05, <jats:italic>ES<\/jats:italic>\u2009=\u20090.58) and during unloaded cycling (<jats:italic>p<\/jats:italic>\u2009=\u20090.05, <jats:italic>ES<\/jats:italic>\u2009=\u20090.58) compared to ICHD. However, thoracic bioreactance derived SV at the GET was significantly higher in adults receiving ICHD versus HHD (<jats:italic>p<\/jats:italic>\u2009=\u20090.01, <jats:italic>ES<\/jats:italic>\u2009=\u20090.74). In adults with ESKD, cardiac output was positively associated with V\u0307O<jats:sub>2<\/jats:sub> at the GET (<jats:italic>r<\/jats:italic>\u2009=\u20090.61, <jats:italic>p<\/jats:italic>\u2009=\u20090.04). This study highlights prevalent exercise dysfunction in adults with ESKD undergoing dialysis, with potential distinct differences between in\u2010centre and home hemodialysis, mechanistically linked to underlying cardiac abnormalities.<\/jats:p>","DOI":"10.14814\/phy2.70050","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T03:13:59Z","timestamp":1726024439000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardiac dysfunction in dialysing adults with end\u2010stage kidney disease is associated with exercise intolerance: A pilot observational study"],"prefix":"10.14814","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9678-4326","authenticated-orcid":false,"given":"Joe","family":"Antoun","sequence":"first","affiliation":[{"name":"Physical Activity, Health and Rehabilitation Thematic Research Group, School of Sport, Health and Exercise Sciences, Faculty of Science and Health University of Portsmouth  Portsmouth UK"},{"name":"Academic Department of Renal Medicine, Wessex Kidney Centre Portsmouth Hospitals University NHS Trust  Portsmouth UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6392-7944","authenticated-orcid":false,"given":"Anthony I.","family":"Shepherd","sequence":"additional","affiliation":[{"name":"Physical Activity, Health and Rehabilitation Thematic Research Group, School of Sport, Health and Exercise Sciences, Faculty of Science and Health University of Portsmouth  Portsmouth UK"},{"name":"Academic Department of Renal Medicine, Wessex Kidney Centre Portsmouth Hospitals University NHS Trust  Portsmouth UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo","family":"Corbett","sequence":"additional","affiliation":[{"name":"Physical Activity, Health and Rehabilitation Thematic Research Group, School of Sport, Health and Exercise Sciences, Faculty of Science and Health University of Portsmouth  Portsmouth UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas C.","family":"Sangala","sequence":"additional","affiliation":[{"name":"Academic Department of Renal Medicine, Wessex Kidney Centre Portsmouth Hospitals University NHS Trust  Portsmouth UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Academic Department of Renal Medicine, Wessex Kidney Centre Portsmouth Hospitals University NHS Trust  Portsmouth UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"Lane","sequence":"additional","affiliation":[{"name":"Physical Activity, Health and Rehabilitation Thematic Research Group, School of Sport, Health and Exercise Sciences, Faculty of Science and Health University of Portsmouth  Portsmouth UK"},{"name":"Queen Alexandra Hospital Portsmouth Hospitals University NHS Trust  Portsmouth UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0674-8477","authenticated-orcid":false,"given":"Zoe L.","family":"Saynor","sequence":"additional","affiliation":[{"name":"School of Health Sciences, Faculty of Environmental and Life Sciences University of Southampton  Southampton UK"},{"name":"National Institute for Health and Care Research, Southampton Biomedical Research Centre University Hospital Southampton NHS Foundation Trust  Southampton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2017.01.009"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.114.001566"},{"key":"e_1_2_8_4_1","first-page":"S1054","article-title":"The role of grip strength and short physical performance battery test in predicting chemotherapy\u2010related outcomes in older adults with cancer","volume":"31","author":"Almugbel F. 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