{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:06:22Z","timestamp":1787022382610,"version":"build-2736575974"},"reference-count":71,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2024,10,6]],"date-time":"2024-10-06T00:00:00Z","timestamp":1728172800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Anabolic\u2010androgenic steroids (AASs) impairment of reproduction has been reported. We investigated dose\u2010 and time\u2010dependent effects of Nandrolone decanoate (ND) on reproductive system in comparison with Testosterone enanthate (TE). Male Wistar rats were administrated with 1, 3, and 9\u2009mg\/kg\/weeks ND or 1 and 3\u2009mg\/kg\/weeks TE for 8\u2009weeks, and testicular phenotype and reproductive hormones were assessed at 4 and 8\u2009weeks post\u2010treatments. AASs \u00d7 treatment period interaction was significant for gonadosomatic index (GSI), testosterone (T), 17\u03b2\u2010estradiol (E\n                    <jats:sub>2<\/jats:sub>\n                    ), and luteinizing hormone (LH). At 4\u2009weeks post\u2010treatment, GSI was decreased in rats treated with 3\u2009mg\/kg\/weeks ND and T was decreased in all ND\u2010treated groups, while no significant changes in LH levels were observed. At 8\u2009weeks post\u2010treatment, GSI was decreased in rats treated with 1 and 3\u2009mg\/kg\/weeks ND and with 3\u2009mg\/kg\/weeks TE, T was decreased in all groups, and E\n                    <jats:sub>2<\/jats:sub>\n                    and LH were increased and decreased, respectively, in rats treated with 9\u2009mg\/kg\/weeks ND and with 3\u2009mg\/kg\/weeks TE. The testes showed histopathological defects in both ND\u2010 and TE\u2010treated rats suggesting a delay in seminiferous cycle. This study shows AASs\u2010induced hypogonadism at low\u2010dose that coincided with inhibition of T biosynthesis and disruption of T feedback on pituitary.\n                  <\/jats:p>","DOI":"10.14814\/phy2.70053","type":"journal-article","created":{"date-parts":[[2024,10,6]],"date-time":"2024-10-06T21:15:33Z","timestamp":1728249333000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Nandrolone decanoate\u2013induced hypogonadism in male rats: Dose\u2010 and time\u2010dependent effects on pituitary and testicular hormonal functions"],"prefix":"10.14814","volume":"12","author":[{"given":"Sholeh","family":"Karimi","sequence":"first","affiliation":[{"name":"Department of Animal Biology, School of Biology, College of Science University of Tehran  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7163-9508","authenticated-orcid":false,"given":"Negar","family":"Kazori","sequence":"additional","affiliation":[{"name":"Department of Animal Biology, School of Biology, College of Science University of Tehran  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3606-1679","authenticated-orcid":false,"given":"Sayyed Mohammad Hadi","family":"Alavi","sequence":"additional","affiliation":[{"name":"Department of Animal Biology, School of Biology, College of Science University of Tehran  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Alijanpour","sequence":"additional","affiliation":[{"name":"Department of Animal Biology, School of Biology, College of Science University of Tehran  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Alim Atif","family":"Siddiqi","sequence":"additional","affiliation":[{"name":"Department of Animal Biology, School of Biology, College of Science University of Tehran  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahman","family":"Zeynali","sequence":"additional","affiliation":[{"name":"Department of Animal Biology, School of Biology, College of Science University of Tehran  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,6]]},"reference":[{"issue":"4","key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"324","DOI":"10.2174\/1381612826666201029101524","article-title":"The protective effect of metformin against oxandrolone\u2010induced infertility in male rats","volume":"28","author":"Abed A. 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