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Because of the pathophysiological role of upregulated mineralocorticoid receptor (MR) signaling in the complications of obesity, this study tested the vasoactive properties of finerenone, a nonsteroidal MR antagonist, in arteries of human AT. Arteries isolated from the visceral AT of obese subjects were studied in a wire myograph. Finerenone resulted in a concentration\u2010dependent relaxation of arteries precontracted with either the thromboxane\u2010A2 analog U46619, ET\u20101, or high\u2010K<jats:sup>+<\/jats:sup> solution; the steroidal MR antagonist potassium canrenoate, by contrast, did not relax arteries contracted with either U46619 or high\u2010K<jats:sup>+<\/jats:sup> solution. Finerenone\u2010induced relaxation after precontraction with U46619 was greater in the arteries of obese versus nonobese subjects. Mechanistically, the vasorelaxing response to finerenone was not influenced by preincubation with the nitric oxide synthase inhibitor L\u2010NAME or by endothelium removal. Interestingly, finerenone, like the dihydropyridine Ca<jats:sup>2+<\/jats:sup>\u2010channel blocker nifedipine, relaxed arteries contracted with the L\u2010type Ca<jats:sup>2+<\/jats:sup>\u2010channel agonist Bay K8644. In conclusion, finerenone relaxes arteries of human visceral AT, likely through antagonism of L\u2010type Ca<jats:sup>2+<\/jats:sup> channels. This finding identifies a novel mechanism by which finerenone may improve AT perfusion, hence protecting against the cardiometabolic complications of obesity.<\/jats:p>","DOI":"10.14814\/phy2.70062","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T02:40:03Z","timestamp":1727232003000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Role of L\u2010type Ca<sup>2+<\/sup>\u2010channels in the vasorelaxing response to finerenone in arteries of human visceral adipose tissue"],"prefix":"10.14814","volume":"12","author":[{"given":"Francesca","family":"Schinzari","sequence":"first","affiliation":[{"name":"Department of Aging Fondazione Policlinico Universitario Agostino Gemelli IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"De\u00a0Stefano","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine Tor Vergata 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