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In this randomized controlled pilot trial, 15 individuals with chronic SCI engaged in 3 times\/week NMES\u2010RT, with (NMES+PRO, <jats:italic>n<\/jats:italic>\u2009=\u20098) or without protein supplementation (NMES, <jats:italic>n<\/jats:italic>\u2009=\u20097), for 12\u2009weeks. Before and after the intervention, whole body and regional body composition (DXA) and fasting glucose and insulin concentrations were assessed in plasma. Adherence to the intervention components was \u226596%. Thigh lean mass was increased to a greater extent after NMES+PRO compared to NMES (0.3 (0.2, 0.4) kg; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Furthermore, fasting insulin concentration and Homeostatic Model Assessment for Insulin Resistance (HOMA\u2010IR) were decreased similarly in both groups (fasting insulin: 1 [\u22129, 11] pmol\u2219L<jats:sup>\u22121<\/jats:sup>; HOMA\u2010IR: 0.1 [\u22120.3, 0.5] AU; both <jats:italic>p<\/jats:italic>\u2009\u2265\u20090.617). Twelve weeks of home\u2010based NMES\u2010RT increased thigh lean mass, an effect that was potentiated by protein supplementation. In combination with the excellent adherence and apparent improvement in cardiometabolic health outcomes, these findings support further investigation through a full\u2010scale randomized controlled trial.<\/jats:p>","DOI":"10.14814\/phy2.70073","type":"journal-article","created":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T04:09:49Z","timestamp":1727928589000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The effect of home\u2010based neuromuscular electrical stimulation\u2010resistance training and protein supplementation on lean mass in persons with spinal cord injury: A pilot study"],"prefix":"10.14814","volume":"12","author":[{"given":"Sven","family":"Hoekstra","sequence":"first","affiliation":[{"name":"Peter Harrison Centre for Disability Sport, School of Sport, Exercise and Health Sciences Loughborough University  Leicestershire UK"},{"name":"Department of Exercise and Sport Science St. Mary's 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