{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:46:40Z","timestamp":1790063200958,"version":"4.0.1"},"reference-count":50,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T00:00:00Z","timestamp":1729209600000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Kawasaki disease (KD) causes vascular injury and lifelong remodeling. Excessive intimal proliferation has been observed, resulting in coronary artery lesions (CALs). However, the mechanisms underlying vascular remodeling in CAL and statin treatment have not been comprehensively elucidated. This study aimed to investigate the effects of statins on vascular remodeling using a KD mouse model.\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    water\u2010soluble substance (CAWS) was intraperitoneally injected in 5\u2010week\u2010old male apolipoprotein\u2010E\u2010deficient mice. They were categorized as follows (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20094): control, CAWS, CAWS+statin, and late\u2010statin groups. The mice were euthanized at 6 or 10\u2009weeks after injection. Statins (atorvastatin) were initiated after CAWS injection, except for the late\u2010statin group, for which statins were internally administered 6\u2009weeks after injection. Elastica van Gieson staining and immunostaining were performed for evaluation. Statins substantially suppressed the marked neointimal hyperplasia induced by CAWS. Additionally, CAWS induced TGF\u03b2 receptor II and MAC\u20102 expression around the coronary arteries, which was suppressed by the statins. KD\u2010like vasculitis might promote the formation of aneurysm by destroying elastic laminae and inducing vascular stenosis by neointimal proliferation. The anti\u2010inflammatory effects of statins might inhibit neointimal proliferation. Therefore, statin therapy might be effective in adult patients with KD with CAL by inhibiting vascular remodeling.\n                  <\/jats:p>","DOI":"10.14814\/phy2.70096","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T21:44:46Z","timestamp":1729287886000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Statin suppresses the development of excessive intimal proliferation in a Kawasaki disease mouse model"],"prefix":"10.14814","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8000-0312","authenticated-orcid":false,"given":"Yusuke","family":"Motoji","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery Kitasato University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuji","family":"Fukazawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Nippon Medical School  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Matsui","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Nippon Medical School  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Nippon Medical School  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiaki","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Nippon Medical School  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Nagi\u2010Miura","sequence":"additional","affiliation":[{"name":"Laboratory for Immunopharmacology of Microbial Products Tokyo University of Pharmacy and Life Sciences  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Kitamura","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Kitasato University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kagami","family":"Miyaji","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Kitasato University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2020.05.034"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1253\/jcj.43.633"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-06272-3"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000484"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3791\/59828"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2021.697632"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/children9091343"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3006927"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aas9432"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2015.10.025"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012369454-6\/50074-1"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.71.709"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-19-1094"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.23736\/S0026-4946.17.04921-0"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a022210"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2010.06.006"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1546-0096-12-12"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1272\/jnms.JNMS.2019_86-206"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/2401693"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/570297"},{"key":"e_1_2_11_22_1","unstructured":"Science Council of JapanGuidelines for proper conduct of animal experiments. 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