{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:12:01Z","timestamp":1789564321500,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T00:00:00Z","timestamp":1729814400000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100005834","name":"Francis Family Foundation","doi-asserted-by":"publisher","award":["2020"],"award-info":[{"award-number":["2020"]}],"id":[{"id":"10.13039\/100005834","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002590","name":"American Lung Association","doi-asserted-by":"publisher","award":["Catalyst 2019"],"award-info":[{"award-number":["Catalyst 2019"]}],"id":[{"id":"10.13039\/100002590","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH\u201019\u20101\u20100377"],"award-info":[{"award-number":["W81XWH\u201019\u20101\u20100377"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["BX004661"],"award-info":[{"award-number":["BX004661"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Type III interferons (\u03bb1, \u03bb2, and \u03bb3) are potent antiviral cytokines in the lung. However, their roles in nonviral lung injuries are less well understood. This study investigates the activation of type III interferon signaling in three distinct models of lung injuries caused by diverse stimuli: the bacterial pathogen Pseudomonas aeruginosa, bacterial endotoxin LPS, and the chemotherapeutic agent bleomycin. Our data show that, despite inducing a potent inflammatory response, Pseudomonas and LPS did not increase IFN\u03bb secretion. In contrast, bleomycin instillation increased secretion of IFN\u03bb in the airways at both early and late time points. Consistent with limited secretion, type III interferon signaling had a minimal role in the host response to both Pseudomonas and LPS, as measured by pathogen burden, inflammatory response, and lung injury. Conversely, a deficiency in type III interferon signaling led to increased inflammatory signaling and elevated acute lung injury in the bleomycin model on day 3. This elevated early injury resulted in impaired recovery in IFNLR1 knockout mice, as evidenced by their recovery from bleomycin\u2010induced weight loss. Taken together, these data suggest a context\u2010specific activation of type III interferon signaling, where it plays an anti\u2010inflammatory role in the lung.<\/jats:p>","DOI":"10.14814\/phy2.70104","type":"journal-article","created":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T22:38:53Z","timestamp":1729895933000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Context\u2010specific anti\u2010inflammatory roles of type\n                    <scp>III<\/scp>\n                    interferon signaling in the lung in nonviral injuries"],"prefix":"10.14814","volume":"12","author":[{"given":"Jingjing","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Shanghai Fifth People's Hospital, Center of Community\u2010Based Health Research Fudan University  Shanghai China"},{"name":"Section of Pulmonary, Critical Care and Sleep Medicine Yale School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jooyoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Section of Pulmonary, Critical Care and Sleep Medicine Yale School of Medicine  New Haven Connecticut USA"},{"name":"Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria D.","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De","family":"Chang","sequence":"additional","affiliation":[{"name":"Section of Pulmonary, Critical Care and Sleep Medicine Yale School of Medicine  New Haven Connecticut USA"},{"name":"Department of Pulmonary and Critical Care Medicine at the Seventh Medical Center, College of Pulmonary and Critical Care Medicine of the Eighth Medical Center Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbo","family":"Liu","sequence":"additional","affiliation":[{"name":"Section of Pulmonary, Critical Care and Sleep Medicine Yale School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8506-0552","authenticated-orcid":false,"given":"William G.","family":"Bain","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"},{"name":"Veterans Affairs Pittsburgh Healthcare System  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keven M.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijun","family":"Jie","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Shanghai Fifth People's Hospital, Center of Community\u2010Based Health Research Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergei V.","family":"Kotenko","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Rutgers New Jersey Medical School  New Brunswick New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles S.","family":"Dela\u00a0Cruz","sequence":"additional","affiliation":[{"name":"Section of Pulmonary, Critical Care and Sleep Medicine Yale School of Medicine  New Haven Connecticut USA"},{"name":"Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"},{"name":"Veterans Affairs Pittsburgh Healthcare System  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3040-9029","authenticated-orcid":false,"given":"Lokesh","family":"Sharma","sequence":"additional","affiliation":[{"name":"Section of Pulmonary, Critical Care and Sleep Medicine Yale School of Medicine  New Haven Connecticut USA"},{"name":"Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania 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