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This study hypothesizes that IBAs play a significant role in the pathophysiology of heart failure. We aim to investigate the impact of these intrapulmonary right\u2010to\u2010left shunts on pulmonary arterial and venous pressures in heart failure patients, utilizing mixed venous oxygen saturation (SvO\u2082) as a key measurement. This study included 237 patients with heart failure who underwent cardiac catheterization. The relationships between SvO\u2082 and pulmonary artery systolic pressure (sPAP), pulmonary artery wedge pressure (PAWP), and left ventricular end\u2010diastolic pressure (LVEDP) were examined using various statistical methods (single regression analysis, partial correlation analysis, structural equation modeling, and Bayesian estimation). All statistical methods that we performed showed that SvO\u2082 was significantly and negatively correlated with both sPAP and PAWP (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01, respectively). However, SvO\u2082 did not significantly correlate with LVEDP. These results suggest that a decrease in SvO\u2082 leads to an increase in PAWP and sPAP, while LVEDP is only passively influenced by PAWP. This phenomenon likely reflects the impact of an intrapulmonary right\u2010to\u2010left shunt caused by IBAs. The decrease in SvO\u2082 causes an increase in sPAP and may also cause an increase in PAWP via IBAs.<\/jats:p>","DOI":"10.14814\/phy2.70128","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T01:54:01Z","timestamp":1732154041000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The relationship between mixed venous blood oxygen saturation and pulmonary arterial and venous pressures in patients with heart failure"],"prefix":"10.14814","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4750-3419","authenticated-orcid":false,"given":"Ryuji","family":"Funaki","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuto","family":"Mashitani","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Oh","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Kashiwagi","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshikazu D.","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohisa","family":"Nagoshi","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Kawai","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michihiro","family":"Yoshimura","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(05)80020-0"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.1999.277.5.L887"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2016.08.063"},{"key":"e_1_2_11_5_1","volume-title":"Physiology, colloid osmotic pressure","author":"Darwish A.","year":"2024"},{"key":"e_1_2_11_6_1","first-page":"353","article-title":"Pulmonary arteries and veins in experimental hypoxia. 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