{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T07:47:48Z","timestamp":1767340068673,"version":"3.41.2"},"reference-count":47,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T00:00:00Z","timestamp":1732060800000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007297","name":"Office of Naval Research Global","doi-asserted-by":"publisher","award":["N00014\u201022\u20101\u20102818"],"award-info":[{"award-number":["N00014\u201022\u20101\u20102818"]}],"id":[{"id":"10.13039\/100007297","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01\u2010NS\u2010122855"],"award-info":[{"award-number":["R01\u2010NS\u2010122855"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Information is scarce on human responses to high pressure exposures out of water, such as related to tunnel construction workers. We hypothesized that differences in the longer durations of exposures for tunnel workers versus underwater divers results in greater inflammatory responses linked to the pathophysiology of decompression sickness (DCS). Blood was analyzed from 15 tunnel workers (36.1\u2009\u00b1\u200910.5 (SD) years old, 6 women) exposed to 142\u2013156\u2009kPa pressure for 4.1\u20134.9\u2009h compared to 8 SCUBA divers (39.3\u2009\u00b1\u200913.3 (SD) years old, 6 women) exposed to 149\u2009kPa for 0.61\u2009hours. Despite differences in pressure duration between groups, elevations were the same for blood microparticles (MPs) (128\u2009\u00b1\u200928% MPs\/\u03bcl) and intra\u2010MPs interleukin (IL\u20101\u03b2) (376\u2009\u00b1\u2009212% pg\/million MPs), and for decreases of plasma gelsolin (pGSN, 31\u2009\u00b1\u200927% \u03bcg\/mL). The number of circulating CD66b\u2009+\u2009neutrophils and evidence of cell activation, insignificant for divers, increased in tunnel workers. Across 3 exposures, the mean neutrophil count increased 150\u2009\u00b1\u200911%. Neutrophil activation increased by 1 to 2% of cells expressing cell surface CD18, myeloperoxidase, platelet\u2010specific CD41, and decrease of cell bound pGSN. We conclude that MPs elevations occur rapidly in humans and reach steady state in minutes with pressure exposures and neutrophil activation requires significantly longer exposure times.<\/jats:p>","DOI":"10.14814\/phy2.70130","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T01:53:42Z","timestamp":1732154022000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Influence of exposure duration on human pressure\u2010induced inflammatory responses: Comparison between tunnel workers and underwater divers"],"prefix":"10.14814","volume":"12","author":[{"given":"Zuha","family":"Imtiyaz","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine University of Maryland School of Medicine  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Owen J.","family":"O'Neill","sequence":"additional","affiliation":[{"name":"US Hyperbaric Inc.  Tarrytown New York USA"},{"name":"Zucker School of Medicine Hofstra University Northwell  Northwell New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas","family":"Sward","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine University of Maryland School of Medicine  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phi\u2010Nga Jeannie","family":"Le","sequence":"additional","affiliation":[{"name":"University of Texas Medical Branch  Galveston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Awadhesh K.","family":"Arya","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine University of Maryland School of Medicine  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veena M.","family":"Bhopale","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine University of Maryland School of Medicine  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4476-1189","authenticated-orcid":false,"given":"Abid R.","family":"Bhat","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine University of Maryland School of Medicine  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3533-6124","authenticated-orcid":false,"given":"Stephen R.","family":"Thom","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine University of Maryland School of Medicine  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,20]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"5969","article-title":"Elevations of extracellular vesicles and inflammatory biomarkers in closed circuit SCUBA divers","volume":"24","author":"Arya A. 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