{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:47:40Z","timestamp":1792842460036,"version":"4.5.0"},"reference-count":47,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T00:00:00Z","timestamp":1732752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R15HL165328"],"award-info":[{"award-number":["R15HL165328"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Non\u2010alcoholic fatty liver disease (NAFLD), now referred to as metabolic dysfunction\u2010associated steatotic liver disease (MASLD), is a silent killer that often progresses to metabolic dysfunction\u2010associated steatohepatitis (MASH). To date, there are no pharmacological treatments for MASLD. While obesity is a major cause of the development and progression of MASLD, the underlying mechanisms remain unclear. We hypothesize that ferroptosis, a recently discovered nonapoptotic iron\u2010dependent form of cell death, is activated during the progression of MASLD and may be a potential target for treating MASLD. Using a murine model of Western diet\u2010induced obesity, C57BL\/6J male mice were exposed to a long\u2010term (36\u2009weeks) Western diet. Controls were maintained with a standard chow diet. Western diet\u2010induced obesity was confirmed by increased body mass index (BMI). Histopathological analysis demonstrated the progression of MASLD to MASH in the obese group, which was accompanied by significant hepatic iron deposition, oxidative damage, and lipid peroxidation. Hepatic ferroptosis was further confirmed by decreased protein expression of glutathione peroxidase 4 (GPX4) and increased acyl\u2010CoA synthetase long\u2010chain family member 4 (ACSL4), markers of ferroptosis. These findings suggest that ferroptosis is a potential mechanism involved in the pathogenesis of MASLD in male mice.<\/jats:p>","DOI":"10.14814\/phy2.70139","type":"journal-article","created":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T00:42:35Z","timestamp":1732840955000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Western diet promotes the progression of metabolic dysfunction\u2010associated steatotic liver disease in association with ferroptosis in male mice"],"prefix":"10.14814","volume":"12","author":[{"given":"Nicole","family":"Maddie","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, College of Osteopathic Medicine New York Institute of Technology  Old Westbury New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nefia","family":"Chacko","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, College of Osteopathic Medicine New York Institute of Technology  Old Westbury New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Matatov","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, College of Osteopathic Medicine New York Institute of Technology  Old Westbury New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2428-6018","authenticated-orcid":false,"given":"Maria Alicia","family":"Carrillo\u2010Sepulveda","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, College of Osteopathic Medicine New York Institute of Technology  Old Westbury New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0237104"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/360438"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.12.054"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw9872"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00401.2007"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.12.012"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-015-1318-7"},{"key":"e_1_2_10_9_1","first-page":"1167","article-title":"Preclinical long\u2010term magnetic resonance imaging study of Silymarin liver\u2010protective effects","volume":"10","author":"Chae Y. 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